Staff Scientist R&D

Natera is a global leader in cell-free DNA testing, specializing in measuring fetal, tumor, or donor cfDNA at the molecular level to inform personalized health care decisions through non-invasive testing.

About the role

We are seeking a highly motivated Staff Scientist to join our rapidly growing assay development team in the Natera R&D Department. In this role, you will be an integral part of high-performing, cross-functional teams developing laboratory tests that positively impact our business and patients. A successful candidate will have deep expertise in molecular biology and a proven track record in developing cfDNA assays through product development cycles. You will lead and support junior scientists and laboratory technicians to plan, execute, and manage scientific studies under design control in a regulated environment, contributing to the improvement and expansion of Natera's state-of-the-art product portfolios.

Responsibilities

• Lead technical projects and associated timelines and deliverables as a subject matter expert; represent the assay development group in cross-functional project teams.
• Drive the planning, design, execution, and reporting of feasibility, development, verification, and validation studies under the design control quality system.
• Collaborate closely with research scientists, automation engineers, biostatisticians, and data scientists to develop new and innovative molecular assays.
• Communicate and document experimental data, scientific findings, and recommendations to R&D and other functions, including Lab Operations, Scientific Affairs, Product Management, Quality, and Regulatory groups.
• May manage Scientists or Research Associates.

Requirements

• BS, MS, or PhD in genetics, molecular biology, biochemistry, or a closely related field.
• PhD with a minimum of 6 years of relevant experience, or an MS degree with a minimum of 8 years of relevant experience.
• Knowledge of high-throughput NGS workflows or other genetic testing applications in clinical settings.
• Experience in developing and validating molecular assays for CLIA lab testing.
• Experience with automation of molecular workflows or assay transfer to automated platforms.
• Experience in managing projects and direct reports.
• Strong interpersonal, analytical, and problem-solving skills.

Skills

• Advanced technical proficiency in long-range PCR techniques, including primer design and optimization.
• Experience with long-read sequencing technologies (e.g., PacBio).
• NGS assay development using Illumina sequencing platforms.
• Proficiency in qPCR, ddPCR, and multiplex PCR.
• Hands-on experience with high-throughput sample processing and automated liquid handling systems in a CLIA-regulated lab.
• Advanced data analysis skills using tools such as JMP and Excel; comfort with programming languages like Python and R, and proficiency with bioinformatics tools and platforms.
• Knowledge of design verification/validation processes compliant with U.S. and E.U. regulatory standards.
• Exceptional communication and presentation skills with meticulous attention to detail.
• Ability to manage multiple priorities in a fast-paced, dynamic environment.
• A proactive, solutions-oriented mindset with demonstrated success in both collaborative and individual projects.

Benefits

• Annual performance incentive bonus.
• Long-term equity awards.
• Comprehensive health benefits (medical, dental, vision).
• 401(k) with company match.
• Generous paid time off and company holidays.
• Additional wellness and work-life benefits.
• Free testing for Natera employees and their immediate families, including fertility care benefits.
• Pregnancy and baby bonding leave.
• Commuter benefits.
• Generous employee referral program.

Pay

Compensation range: $157,300—$196,600 USD. This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.