Staff Scientist in Translational Bioinformatics

About the role

This role is an entry level position for a PhD level professional and a 2nd stage position for those with moderate experience without a PhD. The focus of the position is service-level application of bioinformatics tools and methods to bench and clinical research problems in various biomedical domains.

Responsibilities

• Analyze and integrate datasets from:
  • Single-cell RNA sequencing
  • TCR/BCR repertoire sequencing
  • Spatial transcriptomics
  • Multiplex immunofluorescence/imaging platforms
  • Multiplex protein assays
• Perform cell-state, clonality, pathway, and cell-cell interaction analyses
• Develop reproducible computational workflows in R/Python within HPC environments
• Contribute to manuscripts, abstracts, and grant applications

Qualifications

• Experience with immune repertoire analysis (TCR/BCR sequencing)
• Familiarity with translational immunology and human tissue datasets
• Experience with integrative multi-modal analysis approaches
• Flexibility to work from home for 1-2 days/week

Preferred Qualifications

• Experience with single-cell and/or spatial ‘omics analysis
• Proficiency in R and/or Python
• Strong experience with single-cell and/or spatial ‘omics analysis
• Proficiency in genomic data sets and analysis tools
• Substantial knowledge of technologies commonly used in biological labs
• Substantial knowledge of working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies

Education Qualifications

• Bachelor's Degree Required
• Master's Degree in bio/informatics, computational biology, computer/information science, biomedical engineering, biological science or a related field Preferred
• PhD in Bioinformatics, Computational Biology, Immunology, Genomics, or related field Preferred

Experience Qualifications

• At least three (3) years of applied bioinformatics, computational and/or genomics/proteomics experience Required
• At least five (5) years of applied bioinformatics, computational and/or genomics/proteomics experience Preferred

Skills and Abilities

• Intermediate proficiency in UNIX/LINUX
• Intermediate proficiency in programming languages (Python/Django, R, Perl, Scala, Ruby)
• Intermediate proficiency in pipeline or workflow development frameworks
• Intermediate proficiency in biostatistical data analysis on dimensional data, genomics and research data
• Intermediate proficiency in data management
• Intermediate proficiency in genomic data sets and analysis tools (UCSC Genome Browser, Bioconductor, ENCODE, NCBI databases)
• Intermediate proficiency in open source and commercial bioinformatics resources and software
• Intermediate proficiency in source code management, application development, and project lifecycle management
• Intermediate proficiency in bioinformatics analysis, statistical modeling, data integration, and bioinformatics best practices
• Substantial knowledge of relational database management systems (PostgreSQL, MySQL, Oracle)
• Substantial knowledge of bioinformatics applications and algorithms
• Substantial knowledge of biological domains
• Substantial knowledge of technologies commonly used in biological labs (PCR, cloning, electrophoresis gels, and cell cultures)
• Substantial knowledge of working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies
• Excellent verbal and written communications skills
• Strong time management skills
• Strong organizational skills
• Strong presentation skills
• Strong critical thinking / problem-solving skills
• Strong project management skills
• Ability to maintain confidentiality and professionalism
• Ability to work independently with minimal supervision
• Ability to gather, analyze and make recommendations/decisions based on data / best practices
• Ability to convey complex or technical information in an easy-to-understand manner
• Ability to collaborate with stakeholders at all levels

Benefits

At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting.

Pay

SALARY RANGE: $101,300.00 - $129,100.00 Annually

Schedule

Not specified