SRA / Scientist, Lipid Nanoparticle (LNP) Discovery

Addition Therapeutics is a Series A-stage biotech company in South San Francisco developing gene therapy via the PRINT™ platform.

About the role

The contract SRA/Scientist, LNP Discovery will design, produce, characterize, and optimize lipid nanoparticle formulations to support preclinical research and the development of the company’s novel gene‑supplement technology.

Responsibilities

• Design, formulate, and characterize lipid nanoparticle (LNP) formulations across a diverse range of lipid compositions and therapeutic payloads to support in vitro and in vivo preclinical studies.
• Execute LNP production using microfluidic and jet mixing techniques, ensuring reproducibility, product quality, and scalability.
• Apply expertise in LNP physicochemical characterization techniques, including RiboGreen assays, DLS, zeta-potential, TNS assay, as well as RNA extraction, capillary electrophoresis and endotoxin testing.
• Routinely prepare LNP formulations according to approved protocols for in vivo studies, taking into account the route of administration, animal species, and dose level.
• Coordinate with CROs and travel to in vivo study sites to prepare materials for dosing.
• Contribute to the continuous improvement of LNP production by troubleshooting formulation and process challenges and conducting stability studies to optimize formulation parameters in support of drug product efficacy and safety.
• Collaborate cross-functionally with RNA Process Development, Analytical Development, and In Vivo teams to advance therapeutic programs toward clinical development.
• Maintain rigorous and detailed records of experimental protocols, results, and material inventory in an electronic laboratory notebook (ELN).
• Critically review and analyze data, communicate results and conclusions, present at cross-functional meetings.
• Travel may be required up to 15% of the time.

Requirements / Qualifications

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