Sr. Software Engineer, Clinical Software

Personalis, Inc. is a leader in advanced cancer genomics, enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® adapts to the evolving understanding of cancer, providing biopharmaceutical customers and clinicians with comprehensive genomic and immune system information from a single tissue sample. Personalis operates one of the largest sequencing operations globally and serves as the sole sequencing provider to the Veterans Affairs' Million Veteran Program. Our Clinical Laboratory is built for clinical accuracy, quality, big data, scale, and efficiency, and is GxP-aligned, CLIA-certified, and CAP-accredited.

About the role

We are seeking a Sr. Software Engineer to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will collaborate with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Responsibilities

• Design, develop, test, and maintain software systems and features supporting laboratory operations.
• Develop and optimize backend services and APIs using Python and/or Java.
• Implement solutions using a variety of database technologies, including relational and graph databases.
• Take ownership of deploying and maintaining services in our AWS cloud environment.
• Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
• Troubleshoot and resolve complex technical issues in development and production environments.
• Collaborate with cross-functional teams to translate business requirements into robust technical solutions.

Qualifications

• B.S. degree in Computer Science, Engineering, or a related technical field.
• 5 years of professional software development experience.
• Strong proficiency in at least one programming language such as Python or Java.
• Proven experience building and deploying applications on AWS.
• Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
• Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
• Excellent problem-solving skills and the ability to work independently on complex tasks.

Preferred

• Experience with web frameworks like Flask or FastAPI.
• Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
• Experience in the life sciences, healthcare, or another regulated industry.
• Familiarity with containerization technologies (e.g., Docker).
• Exposure to graph databases or NoSQL technologies.

What You’ll Gain

• Opportunity to take ownership of significant features and projects from design to deployment.
• Deepen your expertise in AWS services and cloud architecture.
• Gain valuable experience working in a regulated life sciences environment.
• Clear pathways for career growth into a senior engineering role through mentorship and impactful work.

Schedule

Onsite: Monday, Tuesday, and Thursday

Pay

The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions. The base pay offered will take into account internal equity and may vary depending on the candidate’s job-related knowledge, skills, and experience. Full-time positions also include an annual performance-based bonus (or sales incentive plan), long-term incentive units (equity), and a full range of medical, financial, and other benefits.

Benefits

• Medical, dental, and vision insurance
• 401(k) match
• Employee Stock Purchase Plan (ESPP)
• Tuition reimbursement
• Paid sick and vacation time
• Commuter benefits and EV charging stations
• Onsite gym and wellness benefits