Sr Scientist I, Discovery Analytical Chemistry

Responsibilities

• Develop project and technical strategy within area of expertise
• Apply advanced scientific principles, theories and concepts to a broad range of research problems and develop innovative solutions for analytical problems related to drug discovery and development
• Design and execute analytical studies to facilitate drug discovery and platform development in various disease areas
• Independently design and initiate development of analytical methods and improvement of existing ones
• Serve as a project coordinator for on-going and new analytical method development
• Work independently and collaboratively with teams to solve scientific /technical challenges
• Develop and validate analytical methods to quantify and characterize drugs and impurities
• Conduct sample analysis, analyze data/results, interpret the outcome of experiments and integrate scientific findings to gain further understanding of drug properties or synthetic/purification route
• Represent team to present research findings to cross-function teams
• Identify, propose and lead areas for initiatives /improvement
• Influence and support drug discovery/development directions with scientific findings
• Train and mentor junior scientists in the team

Requirements

• PhD in analytical chemistry or close related fields with 2+ years relevant industry experience
• Strong hands-on experience of using LC-MS and HPLC for proteins/protein conjugates characterization and quantitation
• Expertise in sample preparation, peptide mapping, MS/MS peptide sequencing, glycosylation analysis, disulfide bond mapping, and post-translational modifications analysis
• In-depth understanding of protein chemistry and analytical chemistry
• Familiar with routine maintenance of mass spectrometers
• Strong troubleshooting and problem-solving skills
• Excellent ability for data interpretation and integration
• Excellent communication and presentation skills
• Ability and willingness to learn cutting edge technologies
• Open mind and willing to learn new technologies
• Hands on experience with CE or MALS is a plus but not necessary