Sr. Principal Scientist, Clinical Pharmacology

About the Company

Neurocrine Biosciences is a leading biopharmaceutical company dedicated to discovering, developing, and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine, and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis*, and uterine fibroids*, as well as a robust pipeline of compounds in mid- to late-phase clinical development. For over three decades, Neurocrine has applied unique insights into neuroscience and the interconnections between brain and body systems to treat complex conditions.

*in collaboration with AbbVie

About the Role

Provides Clinical Pharmacology scientific support for one or more clinical development programs. Leads the planning, execution, interpretation, and communication of Clinical Pharmacology activities and contributes to dose selection and study design across a portfolio that includes diverse therapeutic modalities. Represents Clinical Pharmacology on cross-functional teams and coordinates with partners such as Pharmacometrics, Clinical, Biostatistics, and Regulatory colleagues to ensure high-quality deliverables and recommendations that enable development and regulatory decision-making.

Responsibilities

• Contributes to the development and execution of Clinical Pharmacology strategies for assigned programs or therapeutic areas, aligned with overall development plans.
• Leads the planning, conduct, interpretation, and reporting of pharmacokinetic (PK), pharmacodynamic (PD), and exposure–response activities for clinical development compounds.
• Serves as the Clinical Pharmacology representative on cross-functional program teams, providing scientific input to protocol design, dose selection, and study interpretation across development stages.
• Oversees Clinical Pharmacology deliverables, including analysis plans, reports, and contributions to regulatory documents (e.g., INDs, CTAs, NDAs, briefing books, Investigator Brochures).
• Applies modeling and simulation approaches to inform study design, dose justification, and decision-making, with guidance from senior leadership as needed.
• Manages and oversees external vendors and CROs to ensure high-quality, timely Clinical Pharmacology analyses and deliverables.
• Ensures Clinical Pharmacology activities are conducted in compliance with applicable SOPs, regulatory guidance, and internal standards.
• Communicates Clinical Pharmacology results and recommendations clearly to cross-functional teams and management, including preparation and delivery of scientific presentations.
• Identifies and resolves complex scientific or operational issues within assigned scope, escalating broader strategic risks as appropriate.
• Makes significant contributions to the development of department strategies and policies.
• Mentors and provides scientific guidance to junior scientists and team members.
• Stays current with evolving regulatory expectations, scientific advancements, and industry best practices relevant to Clinical Pharmacology.

Skills

• Excellent interpersonal, communication, problem-solving, and analytical thinking skills.
• Ability to see the broader picture and longer-term impact on the division/company.
• Ability to meet multiple deadlines across a variety of projects/programs with a high degree of accuracy and efficiency.
• Excellent project management and leadership skills.
• Ability to influence all levels of the organization and external resources.
• Ability to drive strategic direction into tactical plans.
• Understanding of the team's place in the larger organization and ability to discuss changes, progress, and issues as they relate to other areas.
• Substantial knowledge of principles and theories and ability to act as a technical lead on various projects.
• Working knowledge of related disciplines to provide solutions to a wide range of difficult problems.
• Ability to work as part of and lead multiple teams.

Qualifications

• Extensive knowledge of pharmacokinetic and pharmacodynamic data interpretation in the context of clinical development.
• Experience as an innovator, drug hunter/developer.
• Extensive knowledge of managing clinical Contract Research Organizations (CROs).
• Proven track record in preparation of INDs, CTAs, NDAs, and MAAs.
• Strong knowledge of in silico modeling and simulation tools.
• Demonstrated knowledge of current regulatory guidances.
• Ability to develop scientific insights from highly complex data sets.
• Good leadership and mentoring skills, typically leading lower levels and/or indirect teams.

Requirements

One of the following combinations of education and experience:

• Bachelor's in chemistry, life sciences, or a closely related discipline and 8+ years of pharmaceutical/biotech experience, including experience in managing clinical Contract Research Organizations, preparation of INDs/CTAs/NDAs/MAAs, and familiarity with in silico modeling and simulation tools.
• Master's in Pharmacokinetics, Pharmaceutical Sciences, or a closely related discipline and 6+ years of similar experience.
• PhD in Pharmacokinetics, Pharmaceutical Sciences, or a related field, or PharmD, and 4+ years of relevant experience.

Pay

The annual base salary range for this role is $156,900.00 - $214,000.00. Individual pay decisions depend on factors such as primary work location, complexity and responsibility of the role, job duties/requirements, and relevant experience and skills. This position also offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in an equity-based long-term incentive program.

Benefits

• Retirement savings plan with company match.
• Paid vacation, holiday, and personal days.
• Paid caregiver/parental and medical leave.
• Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.