Sr. Principal/Principal Scientist

Role Overview

Legend Biotech is seeking a Sr. Principal/Principal Scientist – Flow Cytometry to provide scientific leadership and hands-on expertise in flow cytometry to support cell and gene therapy programs from IND-enabling studies through early- and late-stage clinical development.

Key Responsibilities

• Lead the design, development, optimization, qualification, and validation of multicolor and spectral flow cytometry assays supporting IND-enabling animal studies and clinical trials.
• Provide subject-matter expertise in panel design, antibody and reagent qualification, gating strategies, and data analysis for complex immunophenotyping applications.
• Conduct deep scientific review and interpretation of flow cytometry datasets to support PK/PD, mechanism-of-action, and translational insights.
• Serve as the primary scientific lead for external laboratories and CROs performing flow cytometry assays.
• Oversee assay transfer, validation, execution, troubleshooting, and data delivery at CROs.
• Ensure outsourced activities meet Legend quality standards, regulatory expectations, and program timelines.
• Identify risks related to assay performance, data quality, and operational execution, and implement mitigation strategies.
• Partner with Clinical, Translational Research, Biomarkers, Nonclinical Safety, and Data Science teams to align assay strategy with program objectives.
• Provide scientific input to study design, endpoint selection, and interpretation of bioanalytical results.
• Communicate complex data clearly to multidisciplinary stakeholders.
• Establish and maintain SOPs, best practices, and governance for in-house flow cytometry workflows.
• Mentor and scientifically guide junior scientists and associates.
• Evaluate and implement new technologies, platforms, and analytical approaches to enhance capabilities.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or related discipline with 8+ years (Principal Scientist) or 10+ years (Senior Principal Scientist) of relevant industry experience; or M.S. with 12+ years of experience.
• Extensive hands-on experience with multicolor and spectral flow cytometry platforms.
• Demonstrated experience supporting cell therapy and/or gene therapy programs.
• Strong understanding of bioanalytical method development, validation, and regulatory expectations.
• Proven ability to lead complex programs, influence cross-functional teams, and provide strategic scientific direction.
• Experience overseeing CROs and external vendors.
• Excellent written and verbal communication skills.
• Experience with CAR-T, in vivo gene delivery, or other advanced cell therapy platforms.
• Experience contributing to IND-enabling or regulatory filings.
• Background in translational PK/PD applications of flow cytometry.

Benefits and Paid Time Off

Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay)

$146,410 - $192,164 USD