Sr. Director, Translational Medicine Lead, Autoimmune

We need to output HTML fragment with sections: headings

for sections like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must not repeat job title as heading. We must include sections only when posting has real specific content. We need to extract content. The posting includes: - The Role (description) -> could be "About the role" or "Responsibilities". The text after "Here's What You’ll Do" is responsibilities. Also earlier paragraph about leading translational strategy etc is also role description. We can combine into a "Responsibilities" section. - Here’s What You’ll Need (Basic Qualifications) -> Requirements/Qualifications. - Here’s What You’ll Bring to the Table (Preferred Qualifications) -> could be "Preferred Qualifications" or "Skills". We'll treat as "Preferred Qualifications". - Our Working Model -> maybe "Work Schedule" or "Schedule". It mentions 70/30 work model, in-office, etc. That's schedule info. - Pay & Benefits -> includes benefits description and salary range. So we need Benefits and Pay sections. According to rules, we should only include Pay and Benefits sections if posting actually states them. It does: salary range and benefits list. So we need separate sections for Pay and Benefits? The instruction: "use

for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule)." So we can have separate Pay and Benefits sections. We'll put Pay heading with salary range and bonus info. Benefits heading with list of benefits. - About Moderna -> could be "About the role"? Actually "About Moderna" is company description. Could be "About the role"? Not exactly. Could be "About the company" but not in list. The allowed headings list includes "About the role". We could use that for company overview? Might be okay. Or we could omit if not needed. But we have substantive content about Moderna mission etc. Could fit under "About the role"? Might be a stretch. Perhaps better to include "About the role" as a short paragraph summarizing the role (we already have responsibilities). But we have "The Role Moderna is seeking..." which is role overview. Could be "About the role". We'll use that. - Equal Opportunities, Accommodations, Export Control Notice -> these are boilerplate, should be removed per instruction: remove EEO/equal-opportunity/scam-warning boilerplate. So we omit those. - Also remove cookie/navigation/legal etc. Thus sections:

About the role

-> paragraph summarizing role: The Role Moderna is seeking ... lead translational strategy ... etc. We'll include the paragraph up to "Here's What You’ll Do". Actually we can combine the initial description before "Here's What You’ll Do". Let's capture: "The Role Moderna is seeking an exceptional scientific leader to serve as Senior Director, Translational Medicine Lead – Autoimmune. This individual will lead translational strategy for high-priority and scientifically complex autoimmune programs while helping shape cross-program and modality-level translational strategy across Moderna’s emerging Immune Therapeutics portfolio. The successful candidate will combine deep expertise in human autoimmune immunology and translational drug development with broad understanding of immune tolerance, pathogenic T- and B-cell biology, immune-cell depletion and reprogramming, clinical biomarkers, quantitative pharmacology, and mechanism-based development. This role will operate as a senior scientific leader across program and portfolio teams, strengthen translational capabilities, mentor scientific leaders, establish cross-asset approaches, and influence senior governance and external scientific strategy." That's good. Then

Responsibilities

-> list from "Here's What You’ll Do" bullet points (though they are sentences separated by periods). We'll convert each sentence into

. Need to preserve all substantive information. Let's extract each responsibility sentence: 1. Lead clinical-facing translational strategy for multiple programs and/or the most scientifically complex and business-critical autoimmune assets, integrating disease biology, therapeutic mechanism, patient heterogeneity, pharmacology, biomarker evidence, safety, and clinical outcomes into coherent development strategies. 2. Define the evidence required to establish confidence in mechanism, biological activity, therapeutic window, differentiation, and probability of technical success; anticipate major translational uncertainties and establish focused evidence-generation strategies to resolve them. 3. Shape autoimmune portfolio and modality strategy by establishing common scientific frameworks for immune tolerance, immune reset, durability, relapse, and non-response, and by informing prioritization of programs and indications based on human biology, translatability, biomarker feasibility, and competitive differentiation. 4. Provide senior leadership in human translational immunology, establishing state-of-the-art approaches to evaluate pathogenic and regulatory T-cell biology, B-cell states, autoantibodies, innate immunity, antigen-specific responses, and immune networks in patients. 5. Advance cross-program biomarker and translational technology strategy, including standards for clinical immune monitoring and fit-for-purpose use of high-dimensional flow cytometry, antigen-specific functional assays, immune repertoire analysis, transcriptomics, proteomics, serology, HLA/genetic analysis, and tissue-based approaches. 6. Partner with Clinical and Quantitative Pharmacology to establish integrated PK/PD and exposure-response frameworks connecting dose to target engagement, immune-cell effects, disease biology, safety, and clinical outcomes, including induction, maintenance, retreatment, or boosting strategies where relevant. 7. Shape translational safety strategy by anticipating risks from novel immune biology and integrating mechanistic monitoring into development plans; provide senior scientific leadership in interpreting relationships between efficacy-driving pharmacology and safety. 8. Serve as a senior translational voice in program and portfolio governance, presenting and defending recommendations concerning mechanism, patient population, dose, proof-of-concept, indication expansion, Go/No-Go criteria, and translational probability of success. 9. Lead cross-program reverse translation by identifying patterns across clinical programs, building feedback loops between human data and Research, and ensuring clinical observations influence target selection, modality design, next-generation programs, and portfolio-level understanding of mRNA/LNP behavior in autoimmune applications. 10. Build scientific capability and talent by mentoring Directors, Associate Directors, and scientists; establishing best practices; identifying capability gaps; and leading selected cross-functional initiatives that improve scientific quality, consistency, and speed across Translational Medicine. 11. Lead external scientific engagement with investigators and experts in autoimmune disease, immunology, and translational medicine; represent Moderna in scientific collaborations and appropriate external forums; drive high-impact publication strategies; and support evaluation of external technologies, partnerships, and innovation. 12. Additional duties as may be assigned from time to time. We'll keep all. Then

Requirements

(or Qualifications). The posting has "Here’s What You’ll Need (Basic Qualifications)". We'll use

Requirements

and list each bullet as

. Let's extract: - PhD, MD, MD/PhD, PharmD, or equivalent advanced degree in immunology, autoimmune disease, translational medicine, or a related discipline. - Typically 10+ years of relevant scientific and drug-development experience following advanced training, with substantial biotechnology/pharmaceutical and/or human translational medicine experience. - Demonstrated track record leading translational strategy for multiple clinical-stage immune-mediated or autoimmune programs. - Broad and deep expertise in human immunology and autoimmune disease mechanisms, including strong command of adaptive and innate immunology, T-cell regulation, B-cell and autoantibody biology, antigen presentation, and inflammatory signaling. - Extensive experience with clinical biomarker strategy and biomarker-rich clinical trials, with demonstrated ability to translate complex immune mechanisms and clinical and translational datasets into dose, patient population, proof-of-concept, lifecycle, and other development decisions. - Strong understanding of the end-to-end drug-development process and how translational evidence influences clinical, regulatory, and portfolio strategy. - Demonstrated ability to lead and influence senior stakeholders in complex matrix environments, mentor scientific talent, and communicate effectively at executive level. We'll keep as list. Then

Preferred Qualifications

(or Skills). We'll use

Preferred Qualifications

. List: - Broad development experience across more than one autoimmune disease or therapeutic modality. - Expertise in antigen-specific tolerance, Treg biology, B-cell depletion, immune-cell engineering/reprogramming, or other disease-modifying immune approaches. - Experience with first-in-human development of novel or first-in-class immunomodulatory therapies. - Experience with mRNA therapeutics, lipid nanoparticle delivery, or related emerging modalities. - Experience defining translational strategy from early development through later-stage development and supporting major regulatory interactions involving innovative immune mechanisms or biomarker strategies. - Experience developing cross-program biomarker platforms or translational capabilities. - Strong external scientific network, recognized scientific credibility in autoimmune disease and/or human translational immunology, and a strong publication record. - A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative. Then

Work Model

maybe "Schedule". The posting says "Our Working Model As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. Moderna is a smoke-free, alcohol-free, and drug-free work environment." We'll put under

Schedule

(or Work Model). Use Schedule heading as allowed. Provide paragraph. Then

Pay

-> salary range and bonus info. Paragraph: "The salary range for this role is $196,700.00 - $353,400.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs. The successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance." Then

Benefits

-> list of benefits. We need to extract benefits list from "Pay & Benefits" section: - Competitive healthcare, plus voluntary benefit programs to support your unique needs - A holistic approach to well-being, with access to fitness, mindfulness, and mental health support - Family planning benefits, including fertility, adoption, and surrogacy support - Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown - Savings and investments to help you plan for the future - Location-specific perks and extras We'll put each as

. We should not include "About Moderna" section (the later paragraph about Moderna mission) because it's somewhat boilerplate but could be considered "About the role"? Already we have About the role. The later Moderna description is more about company; could be omitted as not required. The instruction says to remove boilerplate like EEO etc. This is not exactly boilerplate but could be considered company overview. However we already have About the role; we could include a short paragraph about Moderna mission under "About the role" or separate "About Moderna". But the allowed headings list does not include "About the company". So better to omit to avoid extra section. The content is not critical to the role; but it's substantive. However we could incorporate into "About the role" as extra paragraph. But we already have a paragraph about role; adding more may be okay. But to keep sections minimal, we could add another paragraph under About the role after the first paragraph. That would be okay. Thus About the role will have two paragraphs: first as earlier, second about Moderna mission and values. Let's extract that paragraph: "Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets