Senior Scientist, Upstream Process Development (Mammalian Cell Culture)

Responsibilities

• Lead upstream process development for mammalian cell culture systems, including bioreactor optimization, process characterization, and scale-up from bench to pilot scale.
• Design and execute experiments, utilizing Design of Experiments (DoE) methodologies, to enhance cell culture performance, product yield, and process robustness for fed-batch and/or perfusion-based systems.
• Drive the development of new upstream platforms, including the formulation and optimization of novel basal and feed media for CHO cell culture systems.
• Lead the technology transfer of upstream processes to manufacturing sites, ensuring process scalability, authoring technical documents, and aligning scale-down models with manufacturing equipment.
• Collaborate with cross-functional teams (Downstream, Analytical, Manufacturing) and provide technical mentorship to junior scientists to advance biologics production.

Requirements

• Education: PhD in Chemical Engineering, Biochemistry, Biotechnology, or a related scientific field; OR a Master's degree with 3+ years of relevant experience; OR a Bachelor's degree with 5+ years of relevant experience.
• Experience: Hands-on experience in upstream process development for mammalian cell culture (e.g., CHO systems), including direct experience with bioreactor operations at the bench or pilot scale.
• Technical Skills: Demonstrated ability to apply scientific principles to solve process development challenges, coupled with a foundational knowledge of experimental design (DoE), data analysis, and process scale-up principles.

Qualifications

• Direct experience with fed-batch or perfusion processes for monoclonal antibody or recombinant protein production.
• Proven success in technology transfer, process characterization, and working within a cGMP-regulated environment.
• Familiarity with the development, optimization, and evaluation of cell culture media.
• Demonstrated ability to collaborate effectively in cross-functional teams and a passion for mentoring junior scientists.
• Experience in the Animal Health industry.