(Senior) Scientist, Radiopharmacology

About the role

We are seeking an experienced Radiochemist to join Mariana’s Radiopharmacology function, advancing personalized medicine and radiopharmaceuticals. This role will support the development of personalized medicine and radiopharmaceuticals through a strong radiochemistry focus, working with project teams to obtain critical data to advance product development. The position is mainly laboratory‑based and involves developing and optimizing radiolabeling methods for new product candidates, addressing questions from the project team regarding agent stability, in vitro studies, and in vivo biodistribution studies. The candidate will also support broader team activities including pharmacokinetic studies, present data at research meetings, take a leadership role representing the radiopharmacology function for at least one target project, interface with internal cross‑functional teams and potentially external collaborators or CROs, and assist in document preparation such as technical reports. Mariana Oncology’s values include Building a Legacy, Execution Excellence, and Courage of our Convictions.

Responsibilities

• Work closely with other functions to identify necessary studies to drive product advancement
• Perform radiolabeling, product analysis, and subsequent analyses including stability
• Design, develop, and optimize radiolabeling methods and formulations for new agents to support preclinical studies; schedule cell binding and in vitro efficacy studies with Biology, provide radiolabeled molecules, and support in vivo biodistribution and efficacy studies
• Follow relevant SOPs, guidelines and policies in a highly regulated environment
• Accurately label samples, track collection, and maintain comprehensive records
• Follow protocols rigorously and contribute to protocol refinement when needed
• Maintain accurate and organized data entry and analysis (including maintaining the Electronic Lab Notebook in an accurate and timely fashion to ensure compliance with internal quality standards) and compliance with EHS standards
• Communicate in a time‑efficient manner with cross‑functional teams in a dynamic research environment
• Present data to target teams, contribute to written reports and engage with broader company teams
• Execute in vivo studies as required including biodistribution, in vivo efficacy and preclinical imaging studies (PET/SPECT/CT) when necessary
• Knowledge in cell culture is desired but not a requirement
• Experience working with radioactive material is desired but not a requirement – training will be provided where required
• Experience in managing CROs is desired but not required

Requirements

• Bachelor’s Degree in a relevant scientific field, plus 2–5+ years’ experience; MS in a relevant scientific field, plus 1+ year of experience; PhD in a relevant field
• Background in chemistry/radiochemistry
• Interest/experience in pharmacology and/or PK research
• Strong technical writing and oral communication abilities
• Radiopharmaceutical experience is desired, but training will be provided for motivated individuals
• Ability to work with computers and software applications, such as Microsoft Office
• Ability to work in a small team setting and take on significant responsibilities during daily operations

Benefits

• Comprehensive benefits package including strong health insurance, life insurance, disability benefits
• 401(k) with company contribution and match
• Tuition reimbursement
• Generous flexible time off program

Pay

The salary for this position is expected to range between $98,700.00 and $183,300.00 per year, plus a performance‑based cash incentive. The final salary offered is determined based on factors such as relevant skills and experience and will be reviewed periodically upon joining Mariana Oncology. Mariana may adjust the published salary range based on company and market