Senior Scientist, Protein Production

About the Role

Join our Protein Sciences group, an interdisciplinary team with expertise in protein chemistry, enzymology, biophysics, NMR, X-ray crystallography, and electron microscopy. As a Protein Scientist, you will focus on producing proteins to enable structure-guided drug discovery for multiple disease areas. You will design protein constructs, carry out expression in various cell systems, develop purification methodologies, and characterize proteins using biophysical and structural techniques. Collaborate with colleagues within the group and across disease areas to advance early-stage drug development.

Responsibilities

• Develop and execute protocols to generate high-quality protein reagents for small molecule screening, hit validation, and structural biology studies of protein-small molecule complexes.
• Design protein constructs based on literature and AI-based structure prediction tools.
• Express proteins in mammalian and insect cell systems.
• Purify proteins using various chromatography techniques and FPLC equipment.
• Collaborate with colleagues to characterize protein-protein and protein-ligand interactions using biophysical and structural biology techniques.
• Apply critical thinking to troubleshoot experiments and design new approaches.
• Maintain a high level of professional expertise through familiarity with scientific literature and accurate, detailed record keeping.
• Work both independently and collaboratively as part of multidisciplinary teams.
• Present and communicate results with protein science colleagues and project teams.

Requirements

• BS/MS degree in biochemistry, life sciences, molecular biology, or related field with at least 5+ years of relevant research laboratory experience.
• Proven in-depth knowledge and hands-on experience in recombinant protein construct design and expression, including insect cell and mammalian expression systems.
• Proficiency in different protein purification techniques such as affinity, ion exchange, and gel filtration chromatography using FPLC or HPLC systems.
• Understanding of protein characterization and protein-ligand interactions using biophysical methods (e.g., SPR, DSF, ITC, LC/MS).
• Demonstrated critical thinking and troubleshooting ability when handling challenging proteins such as aggregated proteins, multicomponent complexes, or membrane proteins.
• Passionate about biomedical research and drug discovery, with motivation to learn new techniques in protein biochemistry, biophysics, and structural biology.
• Excellent communication skills, both oral and written, and ability to work effectively in a matrix team environment.

Preferred Qualifications

• Experience in protein crystallography, bio-NMR, or cryo-EM, either directly or working closely with others.
• Experience in biophysical methods to characterize protein-protein or protein-ligand interactions.

Pay

The salary for this position is expected to range between $93,800 and $174,200 per year for Senior Scientist I, and $98,700 and $183,300 for Senior Scientist II. The final salary offered is determined based on relevant skills and experience. Compensation includes a performance-based cash incentive and eligibility for annual equity awards.

Benefits

• Comprehensive benefits package including health, life, and disability benefits.
• 401(k) with company contribution and match.
• Generous time off package including vacation, personal days, holidays, and other leaves.