Senior Scientist, Materials Development

Job Description

We are seeking a highly innovative Materials Scientist with deep expertise in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules, including PROTACs, RIPTACs, and molecular glues. This role will support the design of advanced solid form screening approaches, amorphous solid dispersion (ASD) formulations, predictive mathematical models.

Role Responsibilities

• Conduct advanced solid-state characterization of large bRo5 molecules of pharmaceutical relevance.
• Apply novel crystallization techniques to recrystallize bRo5 molecules.
• Support multidisciplinary project teams and collaborate with colleagues to define and implement crystallization, polymorph, salt, and co-crystal screening activities according to project timelines.
• Collaborate with colleagues in Medicinal Chemistry, Formulation and Biopharmaceutics to define and implement screening and characterization strategies consistent with solid form selection for clinical studies.
• Solve scientific problems using contemporary Materials Science experimental techniques.
• Contribute to the development of new scientific approaches and knowledge within the Materials Science organization.
• Ensure contemporaneous and accurate entries are made in the electronic laboratory notebook system according to accepted good practice.

Qualifications

• Master’s Degree (MS) with 2+ years of experience or a PhD in pharmaceutical science, chemistry, chemical engineering, or related field.
• Experience in pharmaceutical solid state characterization techniques (such as x-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, spectroscopy, etc.).
• Strong data analysis and interpretation skills.
• Experience and understanding of infrared spectroscopy (FTIR, NIR, FT-Raman) and/or SSNMR.
• Experience with solving Materials Science problems related to large molecules, e.g., solid state chemistry and particle characterization using experimental approaches and team collaboration.
• Experience with amorphous solid dispersion strategies and ability to develop innovative solid form screening strategies.
• Understanding of physical, analytical, and organic chemistry.
• Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.
• Experience in mathematical modeling.

Additional Information

• The position is full-time, M-F 8 am to 5 pm.
• May be requested to work on weekends, overtime, and holidays based on business needs.
• Candidates currently living within a commutable distance of Groton, CT are encouraged to apply.
• Excellent full-time benefits, including comprehensive medical coverage, dental, and vision options.
• Life and disability insurance.
• 401(k) with company match.
• Paid vacation and holidays.