Senior Scientist II ADC Reaction Engineer

About the role

The Senior Scientist II ADC Reaction Engineer plays a key role in the R&D Process Engineering function. The core deliverable is to develop robust manufacturing processes and advance innovative technologies using strong engineering fundamentals. Key responsibilities include:

• Develop robust manufacturing processes, supporting assets through all phases of development.
• Participate in and/or lead project teams towards development and characterization of new small and large molecule assets. Establish, communicate, and execute research plans.
• Develop commercial ready manufacturing processes in the laboratory and demonstrate the processes in the pilot plant.
• Set project strategies, define project responsibilities and timelines, and provide leadership in a matrixed team setting.
• Address challenging problems with chemical and biochemical reactions, separations, and/or isolations using demonstrated expertise in reaction kinetics, transport phenomena, and mathematical modeling.
• Develop and apply process analytical technologies and data-rich experimentation tools to build appropriate reaction and process understanding via model-guided experimentation.
• Build data-driven and knowledge-driven models to facilitate successful scale-up and tech transfer.
• Author and/or review technical documents summarizing process development efforts and contribute to regulatory filings.
• Exhibit a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively by multi-disciplinary interactions with organic chemists, analytical chemists, process development engineers, pilot plant engineers, drug product development scientists, program managers, and regulatory affairs specialists.
• Author publications and present at scientific conferences.

Responsibilities

• Develop robust manufacturing processes, supporting assets through all phases of development.
• Participate in and/or lead project teams towards development and characterization of new small and large molecule assets. Establish, communicate, and execute research plans.
• Develop commercial ready manufacturing processes in the laboratory and demonstrate the processes in the pilot plant.
• Set project strategies, define project responsibilities and timelines, and provide leadership in a matrixed team setting.
• Address challenging problems with chemical and biochemical reactions, separations, and/or isolations using demonstrated expertise in reaction kinetics, transport phenomena, and mathematical modeling.
• Develop and apply process analytical technologies and data-rich experimentation tools to build appropriate reaction and process understanding via model-guided experimentation.
• Build data-driven and knowledge-driven models to facilitate successful scale-up and tech transfer.
• Author and/or review technical documents summarizing process development efforts and contribute to regulatory filings.
• Exhibit a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively by multi-disciplinary interactions with organic chemists, analytical chemists, process development engineers, pilot plant engineers, drug product development scientists, program managers, and regulatory affairs specialists.
• Author publications and present at scientific conferences.

Requirements

• BS, MS, or PhD in Chemical/Bio Engineering or a related field and 12+ (BS), 10+ (MS), or 4+ (PhD) years of relevant industrial experience.
• Demonstrated capability to model antibody drug conjugate kinetics and mechanisms.
• Experience with drug linker and drug substance process design, including tech transfer and scale-up.
• Development of flow chemistry reactor platforms, including in use for ADCs.
• Experience with highly potent compound handling.
• Leadership of novel reactor configuration development (e.g., photochemistry, electrochemistry, membrane reactors, etc.).
• Expertise in computational fluid dynamics to support reactor design and tech transfer.
• The candidate is expected to demonstrate the ability to solve difficult technical problems and champion new technologies to achieve project goals.
• The candidate is required to be a strong team player and demonstrate scientific leadership, possessing effective oral and written communication skills for facilitating collaborations and leading cross-functional process development teams.

Qualifications

• BS, MS, or PhD in Chemical/Bio Engineering or a related field and 12+ (BS), 10+ (MS), or 4+ (PhD) years of relevant industrial experience.
• Demonstrated capability to model antibody drug conjugate kinetics and mechanisms.
• Experience with drug linker and drug substance process design, including tech transfer and scale-up.
• Development of flow chemistry reactor platforms, including in use for ADCs.
• Experience with highly potent compound handling.
• Leadership of novel reactor configuration development (e.g., photochemistry, electrochemistry, membrane reactors, etc.).
• Expertise in computational fluid dynamics to support reactor design and tech transfer.
• The candidate is expected to demonstrate the ability to solve difficult technical problems and champion new technologies to achieve project goals.
• The candidate is required to be a strong team player and demonstrate scientific leadership, possessing effective oral and written communication skills for facilitating collaborations and leading cross-functional process development teams.