Senior Scientist I, siRNA Pipeline Development & Targeted Delivery

About the role

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas â immunology, oncology, neuroscience, and eye care â and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and TikTok.

Responsibilities

• Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
• Design and execute in vitro and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs.
• Design and execute receptor expression profiling, ligand-receptor binding, internalization, and trafficking assays.
• Evaluate functional delivery and target knockdown in receptor-positive cells and tissues.
• Provide scientific leadership and expertise in candidate nomination and pipeline development.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

Requirements

• BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of experience.
• Demonstrated expertise in siRNA candidate nomination and pipeline development.
• Demonstrated experience in drug delivery platforms, receptor biology and targeted delivery.
• Hands on experience of uptake, trafficking, and functional delivery assays.
• Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

Qualifications

• BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of experience.
• Demonstrated expertise in siRNA candidate nomination and pipeline development.
• Demonstrated experience in drug delivery platforms, receptor biology and targeted delivery.
• Hands on experience of uptake, trafficking, and functional delivery assays.
• Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

Skills

• Hands on experience of uptake, trafficking, and functional delivery assays.
• Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

Benefits

• Comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k).
• This job is eligible to participate in our short-term incentive programs.

Pay

$96,500 - $183,500 USD

Schedule

On-Site