Jobs · Research · California

Senior Scientist, High-Throughput Biologics Production and Discovery Platforms

Bristol Myers Squibb EU Policy · Brisbane, CA · 1 mo ago
On-siteResearch$141k–$171k/yrFull-time
We need to output HTML fragment with sections: About the role? The posting includes a paragraph about company purpose, then Position Summary, Key Responsibilities, Qualifications & Experience, Preferred Qualifications, Compensation Overview, Benefits, How We Work, Supporting People With Disabilities, Candidate Rights, Data Protection. We must remove boilerplate: cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. Also we must not repeat job title as heading. The job title is Senior Scientist (implied). We should not include headings for Job ID etc. We need to include sections only when posting has real specific content. We must not include placeholder like "commensurate with experience". The posting includes compensation range: $141,310 - $171,238. So we can include Pay section. Benefits: they describe benefits. So include Benefits section. Schedule: not mentioned explicitly; they talk about flexible time off, but not schedule like full-time/part-time. Could we infer schedule? Not given explicit schedule; we should not create Schedule section unless posting actually states them. It does not state schedule like "full-time" but mentions full-time employees (FTE) in compensation overview. Could we consider that as schedule? Probably not; better to omit Schedule section. We need headings: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. But we should only include those with content. The posting includes Position Summary (could be About the role). Key Responsibilities (Responsibilities). Qualifications & Experience (Qualifications). Preferred Qualifications could be Skills? Or we could treat Preferred Qualifications as Skills. Benefits and Pay sections. We must not invent headings like About the role if not present; but we have Position Summary which is about the role. So we can use About the role heading. Responsibilities: Key Responsibilities. Qualifications: Qualifications & Experience. Skills: Preferred Qualifications (maybe). Could also include some skills from qualifications but better to separate. Benefits: Benefits. Pay: Compensation Overview. We must not include How We Work, Supporting People With Disabilities, Candidate Rights, Data Protection as those are boilerplate/legal; remove them. Also remove duplicated lines. We need to use

for section headings. Use
  • for any list of duties/requirements/benefits. Use

    for prose. We need to preserve ALL substantive information; do not invent or summarize away detail. So we need to include all details from those sections. We need to format responsibilities as list items. Qualifications as list? Could be list. Preferred qualifications as list. Benefits as list? The benefits description is prose; we could keep as

    but also could list bullet points. The instruction: Use

    • for any list of duties/requirements/benefits. So if we have a list, we must use ul/li. Benefits are described in prose; we could keep as

      . But we could also break into bullet list if we want to follow instruction? It says "for any list of duties/requirements/benefits". If we choose to present benefits as a list, we need to use ul/li. But we can also keep as paragraph; it's not a list. Safer to keep as

      because it's not explicitly a list. Similarly for Pay: we can put compensation range in

      . We need to ensure we don't include any boilerplate like "We hire for skills and capabilities..." that's part of Preferred Qualifications? Actually that sentence appears after Preferred Qualifications: "We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway." That's more of a boilerplate encouragement; but it's part of the posting. Should we keep? It's not a legal boilerplate; it's encouraging applicants. Might be considered part of the posting; we should preserve substantive information. It's not a list; we can include as

      under Preferred Qualifications maybe. We must not include application instructions. That sentence is not exactly instruction to apply but encouragement; still maybe okay. We need to remove duplicated lines: there may be duplicate sentences? Not seeing. Now craft HTML. Structure:

      About the role

      [Position Summary paragraph(s)]

      Responsibilities

      • ...
      • ...

      Qualifications

      • ...
      • ...

      Skills

      [Preferred Qualifications paragraph plus encouragement]

      or we could list as ul if we want. But the instruction: Use
      • for any list of duties/requirements/benefits. Preferred Qualifications is a list of items; we could treat as list. So better to make it a list. Thus:

        Skills

        • Experience with laboratory automation programming and workflow scripting using platforms such as Hamilton VENUS, Tecan FluentControl, Agilent VWorks/Bravo, or comparable systems.
        • ...
        Then after list we can include the encouragement paragraph as

        . Benefits:

        Benefits

        ...

        Pay:

        Pay

        Compensation Overview Brisbane - CA - US: $141,310 - $171,238 The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

        We must not include "Schedule" section. Now we need to ensure we preserve all substantive information from each section. Let's extract the Position Summary text: "At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. Position Summary We are seeking an experienced and highly motivated Senior Scientist to lead and expand high-throughput biologics production capabilities within Discovery Biotherapeutics. This hands-on, laboratory-facing leadership role will oversee the design, execution, optimization, and continuous advancement of integrated protein expression, purification, and quality-control workflows supporting antibody, multispecific, and other biologics discovery programs. The successful candidate will bring deep expertise in transient mammalian protein production, laboratory automation, workflow development, and operational management. The candidate will have a demonstrated record of delivering large, plate-based production campaigns across multiple programs in a fast-paced discovery environment while maintaining high standards for quality, data integrity, safety, and on-time delivery. This individual will serve as both a technical authority and an operational leader, building and sustaining a scalable protein production platform that generates decision-ready data and reliably delivers critical reagents and therapeutic molecules. The role requires close partnership with Protein Sciences, Molecular Biology, Automation, Data Science, Computational Biology, Discovery Biology, and project teams to connect experimental execution with portfolio priorities and integrated discovery workflows. The ideal candidate combines an exceptional wet-lab foundation with enthusiasm for working alongside automation, data science, and computational colleagues. Experience with workflow orchestration or machine-learning-guided discovery is valued but is not required; candidates who have built strong experimental platforms and want to connect them with computational design are encouraged to apply." We need to avoid repeating the job title as heading; we already have About the role heading, not repeating title. We need to preserve all that text. However we should remove the initial fluff about employees asking "Who are you working for?" maybe that's part of company culture; it's substantive? It's not boilerplate; it's describing culture. We'll keep. Now Responsibilities: list each bullet from "Key Responsibilities". Let's extract them: - Lead the build-out, scaling, and day-to-day operation of high-throughput protein production workflows supporting antibody, multispecific, and other biologics discovery programs. - Develop and sustain integrated expression, purification, sample-normalization, and quality-control workflows capable of reliably supporting 60 or more plates per week across multiple concurrent programs. - Provide technical leadership for transient mammalian and cell-free expression platforms, including HEK293 and CHO systems, from DNA preparation through purified protein delivery. - Lead the operation, maintenance, troubleshooting, qualification, and strategic expansion of liquid handlers, robotic workstations, automated purification systems, and integrated analytical instrumentation. - Establish production planning, capacity management, prioritization, performance metrics, and risk-mitigation practices to ensure predictable and timely delivery of high-quality molecules. - Drive workflow development, technology evaluation, process miniaturization, and automation implementation to improve throughput, reproducibility, quality, and operational efficiency. - Partner with Protein Sciences, Molecular Biology, Automation, Data Science, Computational Biology, Discovery Biology, and project teams to align production plans with portfolio priorities and experimental timelines. - Collaborate with automation, data, and computational teams to advance closed-loop discovery workflows and enable structured, traceable data flow from design through experimentation and analysis. - Establish and maintain best practices, standard operating procedures, quality standards, data-integrity expectations, and fit-for-purpose operational documentation. - Lead root-cause analysis and resolution of complex production, workflow, and instrumentation issues, and implement corrective, preventive, and continuous-improvement measures. - Analyze scientific and operational data to identify bottlenecks, reduce cycle time, improve success rates, and expand platform capacity. - Mentor and train scientists and research associates, fostering a culture of technical excellence, accountability, collaboration, innovation, and safe laboratory practices. - Represent the high-throughput production function on cross-functional teams and contribute to platform strategy, resource planning, and capability-development decisions. Now Qualifications & Experience: list each bullet: - Bachelor's degree in bioengineering, structural biology, biochemistry, molecular biology, or a related scientific discipline with 7 or more years of relevant academic and/or industry experience; or a master's degree with 5 or more years of relevant experience; or a Ph.D. with 2 or more years of relevant experience. - Demonstrated success leading large-scale, plate-based protein production operations with high sample volumes, multiple concurrent programs, and demanding delivery timelines. - Extensive hands-on experience designing, operating, managing, and supporting high-throughput protein expression and production workflows in mammalian systems. - Deep expertise in transient mammalian expression platforms, including HEK293 and CHO systems. - Strong knowledge of protein purification technologies, including affinity chromatography, automated purification, sample normalization, and high-throughput quality assessment. - Demonstrated expertise in molecular biology, including the design, optimization, and implementation of scalable cloning strategies and high-throughput DNA fragment generation workflows. - Significant experience operating, maintaining, troubleshooting, and optimizing laboratory automation platforms, liquid handlers, robotic workstations, and integrated instrumentation. - Experience with analytical methods used for protein quality assessment, including SEC, HPLC, SDS-PAGE, Octet, or related technologies. - Demonstrated experience developing scalable workflows, implementing new technologies, and using operational metrics to improve throughput, reliability, quality, and cycle time. - Proven ability to lead complex technical initiatives, independently resolve workflow challenges, manage competing priorities, and deliver results in a matrixed environment. - Strong scientific leadership, mentoring, project-management, organizational, collaboration, and communication skills. Now Preferred Qualifications (Skills): list each bullet: - Experience with laboratory automation programming and workflow scripting using platforms such as Hamilton VENUS, Tecan FluentControl, Agilent VWorks/Bravo, or comparable systems. - Experience with instrument integration, device-driver configuration, interfaces, or automated data-transfer workflows. - Familiarity with laboratory orchestration or scheduling software

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