Senior Scientist, Formulation Delivery Systems

Senior Scientist, Delivery Technologies CSL's organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide. Could you be our next Senior Scientist, Delivery Technologies? Work Environment This position is based in Waltham, MA and is an onsite role 5 days each week. CSL is not providing relocation assistance or visa sponsorship. You will report to the Principal Scientist, Delivery Technologies The successful candidate will provide scientific expertise in the design, formulation, characterization, and optimization of delivery technologies to support drug discovery efforts across multiple functions and external collaborations. This role requires strong expertise in lipid nanoparticle (LNP) formulation, extra-hepatic targeted delivery approaches, siRNA-conjugates to enable tissue- and cell-specific delivery, and extensive knowledge in translational drug delivery sciences. Key Responsibilities Contribute and support CSL’s novel modalities portfolio and pipelineParticipate in external due diligence, assessing delivery system suitability for various modalities, technical feasibility, and riskLead the design, formulation, and characterization of LNPs containing siRNA, mRNA, gene-editing cargoes, and other nucleic acid modalitiesDesign and execute Design of Experiment (DOE) principles in formulation screeningWork on medium to high throughput formulation preparationOptimize formulation parameters, lipid composition, manufacturing processes, and excipient systems to enhance stability and biological performanceDevelop and characterize targeted delivery strategies (t-LNP) utilizing receptor-mediated uptake mechanisms, targeting ligands, and tissue-specific delivery approachesLead efforts related to the design and evaluation of ligand-siRNA conjugates for extrahepatic deliveryEvaluate delivery performance through in vitro and in vivo studies, including cellular uptake, endosomal escape, biodistribution, and target engagementServe as a subject matter expert in delivery approaches and LNP process development, and provide technical delivery-related support across research, development, and manufacturing activitiesApply mechanistic insights into critical process parameters and product attributes through hypothesis-driven experimentation, robust data analysis, and problem-solvingProvide scientific guidance and mentorship to team members and collaborate closely with Analytical Biochemistry and Molecular Biology teams Minimum Qualifications PhD with 5+ years or MS with 7+ years of relevant experience in Pharmaceutical Sciences, Nanomedicine, Biomedical Engineering, Chemistry, Chemical Engineering, Drug Delivery, in the pharmaceutical industry Demonstrated ability to independently lead scientific projects and experience working in cross-functional research environmentsStrong track record in LNP formulation and optimizationExpertise in nanoparticle characterization techniques including particle size, encapsulation efficiency, and stability assessmentExpertise in in vitro and in vivo evaluation of RNA-based delivery systemsUnderstanding of cellular uptake mechanisms, intracellular trafficking, and endosomal escapeDemonstrated experience with targeted LNPs and extrahepatic delivery platformsExperimental design, statistical analysis, and data interpretationPreferred: Knowledge of medicinal chemistry principles related to ionizable lipid design, structure-activity relationships (SAR), ligand optimization and linker chemistry The minimum and maximum base salary range that CSL expects to pay for this position at the Waltham, MA USA work location at the time of this posting is $126,000/yr - $157,000/yr. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.