Senior Scientist, Cell Science

Responsibilities

• Design and execute cell line development workflows, including vector design, transfection, clone screening, and selection for stable expression.
• Perform cell culture experiments involving mammalian cells (e.g., CHO cells) under sterile, aseptic conditions.
• Develop and optimize expression systems, including promoters, selection markers, and gene amplification strategies for high-yield production.
• Screens and characterizes clones for productivity, stability, growth characteristics, and product quality attributes using molecular and biochemical assays.
• Collaborate with project teams and downstream process development scientists to execute protocols, experimental plans, critical production batches, and technology transfers.
• Manage and prioritize multiple projects while supporting and coordinating with other departments to advance company objectives and develop scalable, robust culture processes.
• Write and review Standard Operating Procedures (SOPs) and technical reports for regulatory filings.
• Prepare process transfer documents and cGMP documentation to support the successful implementation of process technologies in clinical and commercial manufacturing operations.
• Collaborate with R&D and the manufacturing team in China, participating in meetings and providing technical support as needed.
• Availability to work weekend and holiday shifts, as required.
• Perform other duties as assigned.

Qualifications

• Ph.D. in Cell Biology or a related field, with 5+ years of relevant experience in the pharmaceutical or biotechnology industry.
• Strong scientific background in recombinant protein expression, cell line development, cellular metabolism, and media optimization.
• Experience in both early- and late-stage bioreactor operations, mammalian stable cell line development, and upstream process development is preferred.
• Demonstrated expertise in advanced technologies for cell line development, with a focus on antibody production.
• Strong knowledge of FDA regulations and other global health authority requirements related to Investigational New Drug (IND) applications, particularly those concerning single stable clone selection and characterization.
• Excellent written, verbal, and interpersonal communication skills.
• Proven ability to perform effectively under pressure, meet tight deadlines, and adapt to shifting project priorities and requirements.
• Experience with high-throughput automated workstations for clone selection is highly desirable.

Pay

The expected base salary range for this position is $90,000 - $140,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.

Benefits

• 100% paid employee premiums for medical/dental/vision, also STD, LTD
• A 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years
• 15 PTO days per year
• Sick leave
• Plus 11 paid holidays