Senior Scientist, Biomarker Laboratory, Flow Cytometry and Immunoassay

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. We seek scientific and business professionals who are highly motivated, collaborative, and share our passionate interest in fighting cancer.

About the role

We are seeking a highly motivated and skilled Senior Scientist to join our Clinical Biomarker laboratory. This role will be responsible for the design, development, validation, and execution of flow cytometry and ligand-binding assays (LBA) to support biomarker strategy and advance clinical drug development programs.

Responsibilities

• Serve as the lead scientist for the development, optimization, and validation of flow cytometry assays (e.g., immunophenotyping, intracellular cytokine staining, receptor occupancy) and ligand binding assays (e.g., ELISA, MSD, Luminex) for clinical biomarker analysis.
• Design experimental plans and lead execution of sample analysis to generate high-quality and robust biomarker data.
• Collaborate with cross-functional teams including translational science, clinical biomarker scientists, clinical biomarker operations, and bioinformatics teams to ensure assay alignment with clinical objectives.
• Provide subject matter expertise in immune monitoring, pharmacodynamic, and safety biomarker analysis; support multi-disciplinary platforms (e.g., molecular assays) if needed.
• Author and review technical documentation including method validation and clinical sample analysis protocols, reports, and SOPs.
• Ensure quality control, data integrity, and timely delivery of analytical results.
• Maintain accurate lab records and mentor junior scientists.

Supervisory Responsibilities

This role is initially an individual contributor. May supervise lab scientists as the team grows.

Qualifications

• Ph.D. in Cell Biology, Molecular Biology, Immunology, or related field with 3+ years or M.S. with 5+ years of relevant industry experience in a clinical, translational, or regulated environment.
• Strong hands-on expertise in multi-parameter flow cytometry (e.g., BD FACSCanto, BD FACSymphony, Cytek Aurora) including panel design, compensation, gating strategies, and data analysis (FlowJo, FCS Diva, FCS Express). Experience with cell sorting is a plus.
• Demonstrated experience in ligand binding assay development using platforms such as MSD, ELISA, Luminex, or Simoa.
• Proven track record in supporting clinical biomarker studies with demonstrated domain expertise and familiarity with relevant regulatory guidance for clinical assays to measure target engagement, receptor occupancy, immunophenotyping, as well as pharmacodynamics endpoints.
• Strong analytical and problem-solving skills with the ability to think critically.
• Excellent communication, organization, and project management skills.
• Experience in lab automation, electronic laboratory notebook (ELN), laboratory information management system (LIMS), and initial lab workflow set-up is a plus.

Skills

• Proficiency in general software such as Microsoft Office (Word, Excel, PowerPoint), Outlook, Zoom, Teams.
• Proficiency in task-related systems e.g., FlowJo, FACS Diva, Softmax.

Travel

Under 10%

Global Competencies

When we exhibit our values of Patients First, Collaborative Spirit, Bold Ingenuity, and Driving Excellence, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Pay

Salary range: $108,800.00 - $148,800.00 annually. Actual compensation is determined by several factors unique to each candidate, including job-related skills, depth of experience, certifications, relevant education or training, and specific work location.

Benefits

• Annual bonus plan (non-commercial roles) or incentive compensation plan (commercial roles)
• Discretionary equity awards and voluntary participation in the Employee Stock Purchase Plan
• Comprehensive benefits package including Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness programs