Senior Scientist, Automated Purifications & Separations

About the role

Join our Analytical, Structural, and Chromatography (ASC) team in Cambridge at an exciting moment — we're establishing new laboratories at Kendall Square and expanding automated purification capabilities for oncology discovery. This is a hands-on, high-throughput separations role in a collaborative team that values productivity, scientific curiosity, and genuine enjoyment of working together.

Responsibilities

• Maintain strong, shared productivity across automated achiral and chiral SFC and RP-LCMS platforms to meet program timelines for libraries, batched singletons, and singleton compounds
• End-to-end workflow execution: Sample preparation through dry-down and reformatting, including robotic transfer to plates and NMR tubes, with clear traceability and smooth handoffs
• Screening and triage: Screen available methods for incoming samples; escalate to the custom purification team when no hits are found, with clear communication of what was tried
• NMR-informed purification science: Use crude and post-purification NMR data to understand recovery, flag science-based themes, and contribute to predictive approaches alongside physical-chemical property data
• Instrument ownership and reliability: First-line troubleshooting and routine user maintenance to maximize automation uptime — working with the team, not in isolation
• Continuous improvement: Identify bottlenecks, contribute solutions, and implement process improvements to increase throughput and data quality
• Cross-functional collaboration: Partner with medicinal chemistry, analytical, structural, and chromatography colleagues to align priorities and deliver purified, characterized compounds
• Contribute to publications, science highlights, and postcards that tell the story of what our team delivers and discovers

Requirements

• PhD in chemistry or related field with 0+ years of relevant separations experience -OR- Bachelor's/Master's with 5+ years relevant experience
• Proven experience with SFC and/or LC-based purification, ideally in discovery R&DD
• Demonstrated ability to work effectively in a lab-based, team environment — collaborative, communicative, and energized by shared goals
• Experience with instrument troubleshooting and hands-on system ownership
• Strong organizational and communication skills
• Operates with integrity, curiosity, and accountability
• Comfortable working with digital tools and data systems, with willingness to learn

Desirable Requirements

• Experience with automated purification platforms and workflow orchestration
• Familiarity with chiral SFC (experience or strong interest in developing capability)
• Exposure to end-to-end automated workflows, including robotics and sample handling
• Experience with light programming, scripting, or workflow customization
• Comfort leveraging modern tools (e.g., light scripting, LLM-assisted coding, cross-vendor software environments)
• Working knowledge of NMR and/or MS as a user
• Interest in advancing data-driven and AI-enabled workflows
• Track record of contributing to publications or scientific communications