Senior Scientist

About the role

A collaborative Senior Scientist position to support the development and execution of in vitro ADME assays for therapeutic candidate evaluation and optimization.

Responsibilities

• Conduct in vitro ADME assays to support drug discovery and candidate optimization.
• Generate, analyze, interpret, and report high-quality data to support project decisions and compound progression.
• Collaborate with DMPK, biology, chemistry, and project team members to ensure timely delivery of decision-enabling data.
• Design and troubleshoot in vitro experiments to address project-specific questions related to compound metabolism, stability, permeability, and protein binding.
• Contribute to LC-MS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
• Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
• Prepare experimental protocols, study summaries, technical reports, and presentations for internal stakeholders and project teams.
• Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
• Support implementation and use of laboratory automation platforms, as applicable.

Requirements

• BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
• Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
• Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
• Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
• Proficiency with data analysis and visualization tools such as Microsoft Excel, GraphPad Prism, Analyst, or similar software.
• Experience using electronic laboratory notebooks.
• Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.
• Strong organizational skills with the ability to manage multiple priorities in a fast-paced, collaborative research environment.
• Excellent verbal and written communication skills, with the ability to present scientific findings clearly to cross-functional teams.
• Demonstrated ability to work independently while contributing effectively in a team-oriented setting.

Qualifications

• BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
• Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
• Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
• Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
• Proficiency with data analysis and visualization tools such as Microsoft Excel, GraphPad Prism, Analyst, or similar software.
• Experience using electronic laboratory notebooks.
• Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.
• Strong organizational skills with the ability to manage multiple priorities in a fast-paced, collaborative research environment.
• Excellent verbal and written communication skills, with the ability to present scientific findings clearly to cross-functional teams.
• Demonstrated ability to work independently while contributing effectively in a team-oriented setting.

Skills

• Hands-on experience with LC-MS/MS-based sample analysis.
• Experience with Sciex instruments.
• Data analysis and visualization skills.
• Experience with electronic laboratory notebooks.
• Laboratory automation platform experience.

Benefits

• Healthcare Insurance
• Dental Insurance
• Vision Insurance
• 401(k) Plan