Senior Scientist, Analytical Chemistry, ADC Technology

About the role

We are seeking a highly motivated Senior Scientist with expertise in LC-MS-based antibody/protein characterization and/or bioanalytical quantitation to support oncology drug discovery. The successful candidate will perform hands-on analytical research focused on antibody-drug conjugates (ADCs), antibodies, and small molecules using LC-MS and HPLC technologies. This role partners closely with multidisciplinary teams to develop, optimize, and apply analytical methods that support discovery and early development programs.

Responsibilities

• Perform analytical characterization and quality control of ADCs, antibodies, and small molecules using LC-MS and HPLC techniques, including:
  • Intact mass analysis
  • De-glycosylation and reducing LC-MS
  • Drug-to-antibody ratio (DAR) determination
  • HPLC methods such as size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), and reverse-phase (RP)
  • Peptide mapping (a plus)
• Prepare and analyze samples from purified proteins and biological matrices, including plasma, serum, and tissues.
• Identify and characterize ADC metabolites from in vitro and in vivo studies using analytical techniques such as affinity capture, forced release, MS/MS, and SIM-MS.
• Develop, optimize, validate, and troubleshoot analytical methods to improve performance and resolve technical challenges.
• Operate, maintain, and troubleshoot analytical instrumentation, such as Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, Agilent HPLC, and UV-Vis systems.
• Evaluate and recommend new analytical technologies and instrumentation to expand internal capabilities.
• Document experimental work in electronic laboratory notebooks (ELNs), maintain analytical databases, and prepare technical reports and project summaries.
• Present experimental results and scientific findings to multidisciplinary project teams.
• Contribute to laboratory operations by maintaining shared equipment, supporting laboratory organization, and improving analytical workflows and efficiencies.

Qualifications

• Ph.D. or equivalent degree in Analytical chemistry or a related field with minimum 5 years' experience, MS degree with 8 years', or BS degree with 11 years'.
• Industry experience in analytical chemistry within the biopharmaceutical or pharmaceutical industry.
• Hands-on experience with protein and bioconjugate characterization using LC-MS, UV-Vis, and HPLC.
• Experience with protein sample preparation techniques, including de-glycosylation, reduction, and enzymatic digestions of ADCs.
• Working knowledge of chromatographic methods, including SEC, HIC, and reverse-phase HPLC.
• Experience operating, maintaining, and troubleshooting LC-MS and HPLC instrumentation.
• Strong analytical and problem-solving skills with excellent attention to detail.
• Ability to manage multiple priorities and work independently in a fast-paced environment.
• Excellent written and verbal communication skills, with the ability to present scientific data to multidisciplinary teams.
• Demonstrated ability to collaborate effectively with cross-functional teams, including chemists, protein engineers, and biologists.
• Scientific curiosity, a passion for innovation, and enthusiasm for evaluating and implementing emerging analytical technologies.
• A publication record in peer-reviewed scientific journals is desirable.