Jobs · Analyst · California

Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms

BioSpace · Redwood City, CA · 2 wk ago
Analyst$50–$69/hrFull-time

Why This Matters

This role accelerates cell and genome therapy research by enabling reliable generation, characterization, and improvement of lentiviral vectors used in discovery and preclinical studies.

Key Responsibilities

  • Design, build, and QC DNA constructs and variant libraries for screening (e.g., mammalian/phage display), including cloning strategy and library design influenced by structure-function analysis.

  • Produce, titer, and QC lentivirus from HEK293T or derivatives; optimize transfection and harvest conditions to improve yield/quality.

  • Maintain rigorous ELN documentation and follow EHS/BSL-2 practices for viral vectors and human-derived materials.

Qualifications

  • Minimum Qualifications: B.S. + 4 years, M.S. + 2 years, or Ph.D. + 1–2 years (or equivalent) in Molecular Biology, Cell Biology, Immunology, Bioengineering, Biochemistry, or related field.

  • Strong molecular cloning and nucleic-acid workflows (vector design, Gibson/In-Fusion, plasmid prep, PCR/qPCR).

  • Library design/build for screening or display (mammalian/phage or related) and support of selection/screen workflows.

  • Lentivirus production in HEK293T/293T (transfection, harvest) plus titering/QC (qPCR/ddPCR, p24, and/or functional assays).

  • Strong mammalian tissue culture (aseptic technique, expansion, banking) and comfort in BSL-2.

  • High experimental rigor, clear ELN documentation, and ability to run multiple experiments in parallel.

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