Senior Research Associate- Diagnostic Assay Development
About the role
The Senior Research Associate will be responsible for executing and optimizing advanced molecular biology assays, particularly those involving Next-Generation Sequencing (NGS) workflows. They will work closely with R&D Scientists, Automation Engineers, and Bioinformatics teams to develop and validate Laboratory Developed Tests (LDTs).
Responsibilities
- Hands-on execution of complex single-cell and spatial genomics assays (sample processing, library preparation, sequencing)
- Systematically troubleshoot, optimize, and refine specific steps within the assay workflow to improve performance, robustness, and efficiency
- Prepare and process samples in support of large-scale clinical research studies
- Generate and maintain meticulous laboratory records, protocols (SOPs), and batch records following Good Documentation Practices (GDP)
- Execute formal experiments for analytical validation studies, including assessment of accuracy, precision, limit of detection, and reproducibility
- Ensure all work is conducted under appropriate quality controls
- Present experimental data clearly and concisely in team meetings and written reports
- Support the transfer of robust assay workflows to the CLIA operations team
- Collaborate closely with R&D Scientists, Automation Engineers, and Bioinformatics teams to meet project milestones
- Work closely with the internal lab operations team to support the maintenance of a high-quality, organized laboratory environment, including inventory management and forecasting, equipment calibration, and ensuring compliance with safety standards
Requirements
- Bachelor's or Master's degree in Molecular Biology, Genetics, Biochemistry, or a related scientific field
- Bachelor's degree with 5+ years or Master's degree with 3+ years of hands-on experience in molecular diagnostics or genomics assay development in an industry setting
- Direct, demonstrable experience with advanced molecular technologies, particularly Next-Generation Sequencing (NGS) workflows
- Exceptional proficiency in molecular biology techniques, including nucleic acid extraction, PCR/qPCR, and NGS library preparation
- A proven track-record of using and optimizing and troubleshooting molecular biology protocols
- Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples)
- Experience working within a quality system or environment governed by CLIA, CAP, or ISO 13485 standards strongly preferred
- Prior hands-on experience with 10x Genomics single-cell or spatial technologies (e.g., Chromium or Xenium platforms) is a strong advantage
- Experience with automated liquid handling for high-throughput assay execution is a strong advantage; experience with microscopy techniques a plus
- Ability to organize, analyze, and interpret complex data sets (e.g., assay metrics, quality control data) and effectively troubleshoot issues based on results
- Commitment to rigorous execution, meticulous record-keeping, and high standards of scientific quality
- Possess excellent communication skills, and can effectively collaborate with interdisciplinary teams, integrating their feedback into your experimental design
- Thrives in fast-paced environments, and excels at managing multiple priorities, adapting to change, and consistently delivering results
Qualifications
Bachelor's or Master's degree in Molecular Biology, Genetics, Biochemistry, or a related scientific field.
Bachelor's degree with 5+ years or Master's degree with 3+ years of hands-on experience in molecular diagnostics or genomics assay development in an industry setting.
Direct, demonstrable experience with advanced molecular technologies, particularly Next-Generation Sequencing (NGS) workflows.
Exceptional proficiency in molecular biology techniques, including nucleic acid extraction, PCR/qPCR, and NGS library preparation.
A proven track-record of using and optimizing and troubleshooting molecular biology protocols.
Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples).
Experience working within a quality system or environment governed by CLIA, CAP, or ISO 13485 standards strongly preferred.
Prior hands-on experience with 10x Genomics single-cell or spatial technologies (e.g., Chromium or Xenium platforms) is a strong advantage.
Experience with automated liquid handling for high-throughput assay execution is a strong advantage; experience with microscopy techniques a plus.
Ability to organize, analyze, and interpret complex data sets (e.g., assay metrics, quality control data) and effectively troubleshoot issues based on results.
Commitment to rigorous execution, meticulous record-keeping, and high standards of scientific quality.
Possess excellent communication skills, and can effectively collaborate with interdisciplinary teams, integrating their feedback into your experimental design.
Thrives in fast-paced environments, and excels at managing multiple priorities, adapting to change, and consistently delivering results.
Skills
- Advanced molecular biology techniques
- Nucleic acid extraction
- PCR/qPCR
- NGS library preparation
- Feasibility studies on new reagents, instrumentation, and process improvements
- Sample processing and preparation
- Data analysis and interpretation
- Quality control and documentation
- Collaboration and teamwork
- Problem-solving and troubleshooting
Benefits
Comprehensive health and retirement benefit programs
Annual bonus program or sales incentive program
Pay
$97,700 - $132,100 USD
Schedule
Full-time
Company
10x Genomics is a company that enables scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future.