Senior Principal Scientist - Translational Muscle Biology

Responsibilities

• Team leadership: Supervise and mentor junior scientists, fostering a collaborative and innovative research environment.
• Project management: Oversee multiple projects, ensuring timely delivery of milestones and effective resource allocation.
• Innovation: Identify and implement new technologies and methodologies to advance muscle cell biology and translational research.
• Model Development: Design, characterize and validate primary cell or stem cell/3D models for therapeutic programs.
• Assay Execution: Lead the design of cell-based assays to assess therapeutic candidates or validate new gene-editing targets.
• Laboratory Work: Maintain a minimum 30% hands-on laboratory contribution to support assay execution, model development, and experimental troubleshooting across neuromuscular translational biology programs.
• Team Collaboration: Collaborate with cross-functional teams to integrate translational biology insights into therapeutic programs or new target proposals.
• Data Management: Document, analyze, and present data to internal teams.

Requirements

• PhD with 15+ years or MS Degree with 20+ years in drug discovery, biology, cellular biology, bioengineering or related field.

Competencies

• Proven ability to lead projects, supervise and mentor scientists.
• Deep knowledge in muscle biology and translational assays.
• Strong assay development and drug discovery knowledge.
• Strong track record of publishing in high-impact journals and presenting at scientific conferences.
• Deep experience with mammalian cell culture, molecular and biochemical assays.
• Strong attention to detail, and enthusiasm for learning.
• Knowledge in mitochondrial biology is a plus.

About the Role

We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle biology.