Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we innovate across the full spectrum of healthcare solutions to deliver breakthroughs that profoundly impact health for humanity.
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. You will work on teams developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Responsibilities
- Apply Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
- Contribute to guiding modeling and simulation strategies within the organization.
- Interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to craft appropriate preclinical and early clinical studies and quantitative model-based analyses.
- Use modeling approaches such as physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to:
- Predict preclinical and clinical PK profiles.
- Quantify exposure/response relationships for target engagement biomarkers, efficacy, and potential adverse effects.
- Guide in vivo and in vitro experimental designs most informative for modeling.
Requirements
- PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 6+ years of relevant industry experience OR a Master's degree with 8+ years of relevant industry experience.
- Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling.
- Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications.
- Excellent interpersonal, organizational, oral/written communication, and teamwork skills.
Skills
- Clinical Pharmacology
- Clinical Trials Operations
- Consulting
- Drug Discovery Development
- Industry Analysis
- Pharmacodynamics
- Pharmacokinetics
- Pharmacology
- Pharmacometrics
- Program Management
- Report Writing
- Researching
- Research Proposals
- Scientific Research
- Tactical Planning
- Technical Credibility
Pay
The anticipated base pay range for this position is $137,000.00 - $235,750.00.
Benefits
- Retirement plan (pension) and savings plan (401(k)).
- Vacation – 120 hours per calendar year.
- Sick time – 40 hours per calendar year (48 hours for Colorado residents, 56 hours for Washington residents).
- Holiday pay, including Floating Holidays – 13 days per calendar year.
- Work, Personal and Family Time – up to 40 hours per calendar year.
- Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child.
- Bereavement Leave – 240 hours for an immediate family member, 40 hours for an extended family member per calendar year.
- Caregiver Leave – 80 hours in a 52-week rolling period.
- Volunteer Leave – 32 hours per calendar year.
- Military Spouse Time-Off – 80 hours per calendar year.
Locations: San Diego, California, USA or Spring House, Pennsylvania, USA.