Senior Principal Scientist - Microscopy

About the Role

Regeneron is seeking an accomplished and innovative scientist to lead the Microscopy function within Imaging Sciences. The successful candidate will be a recognized expert in microscopy with deep expertise in cell biology, advanced optical imaging technologies, quantitative image analysis, and scientific leadership. This individual will provide scientific and strategic leadership for a multidisciplinary microscopy team supporting discovery research, technology development, translational science, and early therapeutic programs across Regeneron's research portfolio.

Responsibilities

• Advance the scientific direction for microscopy and cellular imaging across Regeneron Research, aligning capabilities with priority biological and therapeutic questions.
• Identify, evaluate, validate, and adopt emerging technologies based on scientific value, technical performance, scalability, and portfolio need.
• Provide senior consultation that translates complex biological questions into fit-for-purpose imaging strategies, experimental designs, and quantitative readouts.
• Lead, develop, and retain a high-performing multidisciplinary microscopy team and foster a culture of scientific rigor, collaboration, innovation, and continuous learning.
• Oversee annual strategic, operational, workforce, and capital-equipment plans for the microscopy function.
• Establish governance, metrics, workflows, training, and service models that improve quality, accessibility, reliability, turnaround time, and scientific impact.
• Provide scientific leadership across advanced optical, super-resolution, spectral, lifetime, label-free, live-cell, 3D, high-content, high-throughput, spatial, and translational microscopy approaches.
• Guide method selection, assay development, experimental design, technology troubleshooting, and quantitative image analysis, including machine-learning-enabled approaches.
• Develop scalable imaging infrastructure spanning laboratory automation, robotic image acquisition, image-data management, cloud analytics, AI applications, and digital microscopy.
• Integrate microscopy with molecular imaging, histology, pathology, spatial biology, and other Imaging Sciences platforms to generate coherent, cross-scale evidence.
• Partner with discovery, translational, platform, engineering, data science, and technology teams to deliver imaging strategies that inform target validation, mechanism-of-action studies, biomarker development, candidate selection, and translational planning.
• Mentor microscopy scientists and imaging specialists, build technical depth and scientific leadership, and train researchers in microscopy best practices and experimental design.

Requirements

• Ph.D. in Cell Biology, Cellular Physiology, Developmental Biology, Molecular Biology, Bioengineering, Biophysics, or related discipline.
• Minimum 5 years of relevant postdoctoral and/or industry experience.
• Minimum 5 years leading a microscopy core facility or equivalent scientific organization.
• Demonstrated expertise developing and applying advanced microscopy methodologies to answer complex biological questions.
• A strong publication record with evidence of leadership as a primary or senior contributor in microscopy-driven research.
• Deep understanding of cell biology, optical physics, microscopy instrumentation and mechanics, image formation, fluorescent probes and reporters, automation, and quantitative image analysis.
• Experience selecting, implementing, and optimizing advanced microscopy imaging platforms.
• Demonstrated success managing scientific staff and multidisciplinary teams.
• Strong project management and stakeholder engagement experience.

Qualifications

• Recognized external reputation in biological microscopy or imaging sciences (preferred).
• Experience building or transforming an imaging core facility (preferred).
• Working knowledge of machine learning and AI-driven image analysis (preferred).
• Experience with spatial omics and multiplexed imaging platforms (desirable but not required).
• Experience integrating microscopy with in vivo imaging, pathology, and translational biomarker efforts (preferred).
• Record of successful strategic technology adoption and innovation (preferred).

Location

Tarrytown, NY, United States – On-site

Pay

Salary Range (annually): $150,500.00 - $245,500.00