Senior Principal Scientist, Cancer Immunology, Discovery Biology, Oncology Thematic Research Center

About the role

The Oncology Thematic Research Center at Bristol Myers Squibb is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The Oncology teams drive novel therapeutic interventions exploiting tumor intrinsic pathways and mechanisms of cancer immunology to treat tumors that are refractory to current treatments.

Responsibilities

• Lead matrixed TCE / cancer immunology discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation.
• Deploy existing and new techniques for function-based identification and selection of lead drug candidates.
• Leverage experience and insights to shape overall strategy and inform the next wave of therapeutic innovation.
• Collaborate with functional area leads e.g. pharmacology, DMPK, bioinformatics to drive programs forward, including helping to define program priorities and risks.
• Collaborate with multi-disciplinary teams from external partners to help drive assets forward.
• Present complex concepts to a range of audiences including governance and full team project meetings.
• Utilize excellent communication and interpersonal skills.
• Communicate via email, meetings, and reports.

Requirements

Basic Qualifications:

• Bachelor’s Degree 10+ years of academic and / or industry experience
• Master’s Degree 8+ years of academic and / or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of academic and / or industry experience
• 2+ years of leadership experience

Preferred Qualifications:

• Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of industry experience
• 2+ years of leadership experience
• Experience developing novel immune therapeutic approaches for cancer including T cell redirected therapies.
• Experience leading teams charged with profiling and developing complex biologics to drive enhanced immune function in the tumor microenvironment, with a strong preference for experience in discovery of T cell engagers.
• Experience in both high throughput screening, and biologically complex, cell based assays to drive mechanistic insight and prioritization of therapeutic leads.
• Experience in interpreting in vivo functional assays.
• Experience leading and collaborating across matrixed discovery programs from concept to IND including with immune cell engagers.
• Experience contributing to an IND.
• Strong leadership, interpersonal, and communication skills.
• Able to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
• Able to summarize and interpret complex scientific data in a clear, concise, and accurate manner.
• Experience leading, coaching and mentoring a team of lab-based in vitro biologists.
• Excellent oral and written communication skills.
• Able to communicate well with peers, supervisors, and governance committees.
• Strong problem-solving skills and understanding of complex scientific principles and demonstrated experience leveraging AI to refine strategic and tactical planning.

Qualifications

• Bachelor’s Degree 10+ years of academic and / or industry experience
• Master’s Degree 8+ years of academic and / or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of academic and / or industry experience
• 2+ years of leadership experience

Skills

• Experience developing novel immune therapeutic approaches for cancer including T cell redirected therapies.
• Experience leading teams charged with profiling and developing complex biologics to drive enhanced immune function in the tumor microenvironment, with a strong preference for experience in discovery of T cell engagers.
• Experience in both high throughput screening, and biologically complex, cell based assays to drive mechanistic insight and prioritization of therapeutic leads.
• Experience in interpreting in vivo functional assays.
• Experience leading and collaborating across matrixed discovery programs from concept to IND including with immune cell engagers.
• Experience contributing to an IND.
• Strong leadership, interpersonal, and communication skills.
• Able to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
• Able to summarize and interpret complex scientific data in a clear, concise, and accurate manner.
• Experience leading, coaching and mentoring a team of lab-based in vitro biologists.
• Excellent oral and written communication skills.
• Able to communicate well with peers, supervisors, and governance committees.
• Strong problem-solving skills and understanding of complex scientific principles and demonstrated experience leveraging AI to refine strategic and tactical planning.

Benefits

Bristol Myers Squibb offers a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.