Senior Principal Scientist

Main Responsibilities

• Serve as subject matter expert for mast cell disorders and related rare immune and hematologic conditions, providing scientific leadership and strategic guidance.
• Drive early discovery initiatives by directing target identification, mechanistic biology research, and preclinical strategy development for first-in-class and best-in-class rare disease therapeutics.
• Initiate and lead new preclinical programs to strategically expand the rare disease pipeline and advance innovative treatment options.
• Identify and leverage cross-portfolio synergies with rare blood disorders and hematopoietic stem cell programs to maximize therapeutic opportunities and optimize resource allocation.
• Monitor competitive landscape and establish strategic partnerships through targeted academic collaborations and business development initiatives.
• Partner cross-functionally with Clinical and Business Development teams to develop indication expansion and lifecycle management strategies, supporting comprehensive portfolio development from discovery through commercialization.
• Contribute to organizational excellence through strategic planning, executive communications, scientific publications, and regulatory submissions that advance company objectives.

About You

• Earned Ph.D. in molecular biology, cellular biology, hematology, immunology, or related discipline PLUS at least 7 years research experience in biopharmaceutical setting.
• Experience in hematopoietic stem cell and mast cell research, including systemic mastocytosis.
• Experience in early and late-stage research.

Skills And Competencies

• Ability to weigh and integrate inputs and opinions from broad range of stakeholders with diverse backgrounds.
• Ability to capture and distill complex data, concepts, and information into clear, well-articulated messages to guide and drive decision-making.
• Ability to multi-task and adapt to rapidly changing priorities and deadlines.
• Excellent critical thinking, analytical, and problem-solving skills.
• Excellent written and oral communication skills, with the ability to communicate effectively in a multidisciplinary teams as well as to senior leadership.
• Strong interpersonal skills, with the ability to build excellent working relationships.