Senior Principal Scientist, Analytical Sciences

Responsibilities

• Implement and refine analytical testing strategies for circular RNA and lipid nanoparticle (LNP) formulations.
• Develop and optimize drug substance and drug product LC-MS/MS assays for quantification, characterization; perform in-depth characterization studies for lead candidates and pipeline programs.
• Troubleshoot complex hardware and software issues on high-resolution MS platforms.
• Lead method transfer activities to external partners, providing technical oversight, troubleshooting, and ensuring assay robustness and compliance.
• Author and review methods, reports, and SOPs to ensure alignment with regulatory expectations.
• Generate high-quality data packages; analyze, interpret, and present findings to cross-functional R&D teams.
• Foster a positive, innovative, and entrepreneurial team culture; contribute to scientific strategy and continuous improvement initiatives.

Requirements

• M.S. or B.S. degree in molecular biology, cell biology, biochemistry, or chemistry plus assay development experience and the following: 7+ years’ LC-MS and relevant industry experience (M.S.), or 10+ years’ LC-MS and relevant industry experience (B.S.).
• Full competency in all aspects of bioanalysis by LC-MS/MS including method development, execution of quantitative assays, critical review of data, and communication of scientific results.
• Hands-on expertise with complex LC-MS operations, method development, troubleshooting, and maintenance of advanced platforms including QTOF, Orbitrap or triple quadrupole mass spectrometers.
• Experience with various techniques such as IP-RP, AEX, SEC-MALS, and LC-CAD for characterization and release testing for quantifying RNA, Lipids and proteins in complex biological matrices.