Senior Principal Scientist, Aging and Metabolism

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

This position is a hybrid role and can be located in Spring House, PA or Cambridge, MA.

Responsibilities

• Project and Portfolio Leadership:
  • Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
  • Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
  • Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
  • Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
  • Present scientific strategies and recommendations to senior leadership and governance committees.
• In Vitro And Translational Pharmacology:
  • Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
  • Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
  • Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
  • Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
  • Serve as a subject matter expert, ensuring scientific rigor, quality, reproducibility, and translational relevance across programs.
• Cross-Functional Leadership:
  • Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
  • Provide scientific mentorship and leadership across matrix teams.
  • Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

Qualifications

• A minimum of a Ph.D. in Pharmacology, Physiology, Cell Biology, Molecular Biology, Biochemistry, Biomedical Sciences, or a related scientific discipline is required.
• A minimum 10 years of pharmaceutical or biotechnology experience is required.
• Demonstrated experience in the following is required: in vitro pharmacology; target validation; assay development; mechanism-of-action studies; translational research.
• Strong knowledge of the following is required: receptor pharmacology; GPCR biology; cell signaling; biomarkers; PK/PD; translational medicine.
• Experience in the following is preferred: muscle biology; aging biology; metabolism; obesity; cardiovascular disease; heart failure.
• Experience supporting the following is preferred: biologics; multi-specific antibodies; peptide therapeutics; RNA-based medicines; gene-silencing technologies; targeted delivery platforms.
• Experience evaluating external innovation and business development opportunities is preferred.
• Proven ability to provide leadership within multidisciplinary drug discovery teams is required.
• Must have excellent verbal and written communication skills.
• Must be strategic with a strong scientific mindset.
• The ability to operate effectively within a highly coordinated, fast-paced matrix environment is required.

Skills

• Required Skills: In vitro pharmacology, target validation, assay development, translational research, receptor pharmacology, GPCR biology, cell signaling, biomarkers, PK/PD, translational medicine, leadership in drug discovery teams, communication, strategic thinking.
• Preferred Skills: Big Data Management, Data Reporting, Drug Discovery Development, Molecular Diagnostics, Pharmaceutical Microbiology, Problem Solving, Product Development, Product Knowledge, Project Reporting, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Tactical Planning, Technical Credibility, muscle biology, aging biology, metabolism, obesity, cardiovascular disease, biologics, multi-specific antibodies, peptide therapeutics, RNA-based medicines, gene-silencing technologies.

Pay

The anticipated base pay range for this position is $137,000.00 - $235,750.00.

Benefits

• Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
• This position is eligible to participate in the Company’s long-term incentive program.
• Vacation – 120 hours per calendar year.
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado – 48 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year.
• Holiday pay, including Floating Holidays – 13 days per calendar year.
• Work, Personal and Family Time - up to 40 hours per calendar year.
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child.
• Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year.
• Caregiver Leave – 80 hours in a 52-week rolling period.
• 10 days Volunteer Leave – 32 hours per calendar year.
• Military Spouse Time-Off – 80 hours per calendar year.