Senior Medical Director, Oncology Clinical Development

About the Company

Zai Lab is a patient-focused, innovative, commercial-stage, global biopharmaceutical company based in China and the United States. We are dedicated to discovering, developing, and commercializing best-in-class and first-in-class therapies that address medical conditions with significant unmet needs in oncology, immunology, neuroscience, and infectious disease. Guided by innovation and driven by purpose, our mission is to leverage our expertise and resources to make a lasting, positive impact on human health worldwide.

Zai Lab’s global team of 2,100 talented professionals includes industry leaders and professionals dedicated to advancing novel therapies to patients. With headquarters in Cambridge, Massachusetts, and Shanghai, and teams in the U.S., China, and Europe, we collaborate across time zones to deliver meaningful impact where it’s needed most. Founded in 2014 by Dr. Samantha Du, Zai Lab was purpose-built to become a leading global biopharma, combining scientific innovation, operational scale, and strong execution.

Our global pipeline features ZL-1310, a DLL3 antibody-drug conjugate (ADC) with best-in-class and first-in-class potential in small cell lung cancer, now in clinical trials. Our R&D team is also progressing several other global programs into the clinic, including ZL-1503, a bispecific IL-13/IL-31 antibody for atopic dermatitis, and ZL-6201, an LRRC15 ADC for solid tumors.

In China, we’ve earned a reputation as a partner of choice for leading global biopharmaceutical companies, leveraging our proven commercial infrastructure and clinical trial capabilities to accelerate market access to our innovative products. Due to its large population, China is the second largest pharmaceutical market in the world. Our unique business model combines in-licensed assets with strategic partnerships, leveraging our in-house research capabilities to build a regional portfolio of late-stage, potential best-in-class and first-in-class therapies. Today, with eight products on the market in China, we are delivering meaningful impact for patients and building opportunities for talented professionals to shape the future of medicine.

Zai Lab is publicly traded with dual-primary listings on both the Nasdaq Stock Market and the Hong Kong Stock Exchange, underscoring our commitment to transparency, global reach, and long-term growth.

Responsibilities

• Provide medical leadership for the design and execution of late-stage clinical trials, including pivotal and confirmatory studies. Collaborate closely with clinical operations to ensure trials are conducted in alignment with scientific objectives, patient safety standards, and regulatory requirements.
• Serve as Medical Monitor for Phase III and registration trials, ensuring patient safety, protocol compliance, and timely medical oversight. Review safety data, support data monitoring activities, and act as the primary medical contact for study teams and investigators.
• Contribute expert medical and scientific leadership to clinical development strategies, regulatory submissions, and lifecycle planning.
• Work closely with regulatory affairs, clinical operations, pharmacovigilance, biostatistics, medical affairs, and commercial teams to align clinical and business objectives.
• Represent Zai Lab in interactions with investigators, key opinion leaders, regulatory authorities, and external collaborators.
• Analyze clinical trial data and real-world evidence to identify trends, assess efficacy and safety signals, and support data-driven decision-making. Collaborate with cross-functional teams to translate findings into actionable insights that inform clinical strategy, regulatory submissions, and program advancement.
• Develop strategies for label expansion, post-marketing commitments, and long-term product differentiation.
• Lead the preparation of regulatory documents, participate in health authority interactions globally, and contribute to risk management planning and mitigation strategies throughout the development lifecycle.
• Provide clinical expertise to support licensing opportunities, partnerships, and due diligence activities.
• Build strong relationships, challenge ideas constructively, and drive impactful decision-making based on scientific evidence.
• Maintain up-to-date knowledge of oncology trends, the competitive landscape, and regulatory changes to inform clinical strategy.
• Work across several time zones and travel up to 30%.

Requirements

• MD with board certification in Oncology, Hematology-Oncology, or a related specialty.
• Five years of clinical development experience, with a focus on late-stage oncology trials.

Qualifications

• Proven track record as a Medical Monitor for pivotal trials and successful regulatory submissions.
• Deep understanding of oncology drug development, clinical endpoints, and regulatory pathways.
• Proven ability to lead cross-functional teams and manage complex clinical programs.
• Clinical practice experience or experience as an investigator is a plus.
• Excellent leadership, strategic thinking, and communication skills.
• Strong collaboration skills to effectively interact with internal and external stakeholders.
• Demonstrated commitment to high personal values and ethical standards.

Pay

The pay range for this position at commencement of employment is expected to be between $292K and $409K/year. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package may also include a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave).

Benefits

• Medical, financial, and other benefits, including 401(k) eligibility.
• Paid time off benefits, such as vacation, sick time, and parental leave.

About Zai Lab

At Zai Lab, we are proud of the gender diversity of our company and our promotion of women in biotech. We have achieved gender base pay equity at all levels, 59% of our employees are women, and 53% of our management positions are held by women. We are committed to the health of patients and our planet. That’s why our environmental protection, social responsibility, and corporate governance strategy, called “Trust for Life,” is integrated within our business.