Senior Manager, R&D Accounting

About the role

Senior Manager, Research & Development (R&D) Accounting to lead the accounting and financial reporting for the Company's research and development activities. Reporting to the Director, Accounting, this individual will be the primary owner of the monthly R&D close process, ensuring the accurate accounting of clinical trial costs, CROs, CMC activities, and other development-related expenditures. This role partners closely with Clinical Operations, Clinical Development, CMC, FP&A, Program Management, and external vendors to ensure timely, accurate financial reporting while supporting business decision-making. The ideal candidate has deep biotechnology or life sciences R&D accounting experience, strong general ledger expertise, excellent analytical skills, and thrives in a collaborative, fast-paced environment.

About Avalo Therapeutics

Avalo Therapeutics is a clinical stage biotechnology company dedicated to developing therapeutics targeting the IL-1β pathway for immune-mediated inflammatory diseases. Avalo is advancing its lead anti-IL-1β monoclonal antibody (mAb) drug candidate, abdakibart, into a phase 3 registrational program in hidradenitis suppurativa (HS), a chronic inflammatory skin condition that affects an estimated 1–4% of the population globally. Avalo is pursuing additional development opportunities in IL-1β driven indications. Avalo is also developing AVTX-010, a long-acting next-generation anti-IL-1β mAb.

Responsibilities

• Lead the monthly accounting and close process for all R&D-related activities in accordance with U.S. GAAP and company policies.
• Own the monthly R&D accrual process, including vendor outreach, meetings with internal stakeholders, accrual and prepaid analysis, preparation of supporting schedules, and complex journal entries.
• Prepare and review journal entries, account reconciliations, and supporting schedules related to:
  • Clinical trial expenses
  • CRO contracts and related services, investigator grants and site payments, and pass through costs
  • CMC and manufacturing activities
  • Central laboratory expenses
  • External research collaborations
  • Preclinical research
  • Other R&D development costs
• Serve as the primary accounting partner to Clinical Operations, Clinical Development, CMC, Program Management, FP&A, and external vendors, ensuring accurate financial reporting and proper period recognition of R&D related expenses.
• Prepare key R&D analyses and reporting for the monthly, quarterly, and annual close, including significant contributions to management close presentations.
• Prepare complex balance sheet reconciliations, and account analyses.
• Analyze financial results, investigate variances, and