Senior Manager, Clinical Operations - Cardiology

About the role

This role serves as a strategic advisor to sponsors, CROs, and research sites, translating operational challenges into scalable solutions that improve study execution, accelerate activation timelines, and drive patient recruitment performance.

Responsibilities

• Own the end-to-end site activations, managing timelines, dependencies, and risks across multiple concurrent sites and trials
• Help teams prioritize tasks and ensure milestones are met within defined SLAs
• Maintain activation plans, status tracking, and documentation, escalating risks and delays proactively
• Serve as the primary operational partner to sponsors, CROs, and sites throughout the trial lifecycle
• Lead and support sponsor, CRO, and partner meetings by providing clinical operations expertise, actionable insights, and strategic recommendations
• Build strong relationships with key stakeholders and ensure alignment on study goals, performance metrics, and operational priorities
• Proactively communicate study risks, mitigation plans, and escalation strategies
• Facilitate educational sessions, webinars, and customer forums to strengthen engagement and share best practices
• Travel as needed to customer sites, investigator meetings, conferences, and sponsor engagements (up to 15%)
• Monitor study performance metrics and own activation-specific reporting, including time-to-activation, SLA performance, and root causes of delays
• Build and maintain dashboards that provide clear stakeholder visibility
• Use data to inform prioritization, process improvements, and resourcing decisions
• Identify operational gaps affecting site activation, enrollment, and execution, and collaborate cross-functionally to address them
• Advocate for site needs and serve as a subject matter expert in clinical research operations
• Partner with sponsors and CROs to streamline processes and optimize site activation timelines

Requirements

• Bachelor's degree or equivalent combination of education and experience
• 8+ years of experience supporting Phase II-IV sponsor-funded clinical trials
• Deep understanding of clinical trial operations, including study startup, feasibility, regulatory processes, protocol execution, and GCP requirements
• Experience working directly with sponsors, CROs, investigative sites, and cross-functional stakeholders
• Demonstrated ability to manage multiple priorities, navigate ambiguity, and drive projects to successful completion
• Strong analytical, communication, and stakeholder management skills
• Comfort adopting and leveraging new technologies and operational tools
• Willingness to travel up to 30%

Preferred Qualifications

• Experience in cardiology clinical research
• Prior project or program management experience
• 5+ years of experience as a Clinical Research Associate (CRA) or Clinical Research Coordinator (CRC), or 3+ years leading clinical operations teams
• Experience with CTMS platforms, with RealTime CTMS strongly preferred
• Experience working in a high-growth or startup environment
• Experience presenting to sponsors, CRO leadership, and executive stakeholders

Benefits

• Hybrid work environment with in-office collaboration two days per week in either our NYC or Boston office
• Comprehensive medical, dental, and vision coverage, with up to 80% of premiums covered by Iterative Health
• Mental health and wellness support through Spring Health
• Health HSA or FSA options, and commuter FSA contributions supported by Iterative Health
• Unlimited PTO, 12 company holidays, and a company-wide shutdown between Christmas and New Years
• 401(k) program with a company match of up to 3% (up to $3,000 annually)
• Weekly in-office lunch benefit every Tuesday
• 100% company-paid short-term and long-term disability coverage
• Annual wellness and professional development stipend to support your health and growth