Senior Manager / Associate Director, Gross-to-Net & Revenue Planning

About the Role

The Senior Manager / Associate Director, Gross-to-Net (GTN) & Revenue Planning will own gross-to-net, revenue forecasting, and commercial operating expense forecasting for Orca Bio's first commercial product. Reporting to the Senior Director/Head, FP&A, this role establishes the accrual methodology, forecast architecture, documentation, and monthly cadence that a newly commercial company requires — in a product setting where individual transactions are material and where there is limited precedent to inherit. The position requires strong technical judgment, cross-functional partnership, and deep expertise in pharmaceutical revenue deductions and government pricing. This is a hands-on individual contributor role.

Responsibilities

• Cross-Functional Ownership & Key Interactions: Perform the methodology, calculation, and reconciliation work for gross-to-net activities typically split into Accounting, while Controllership retains accountability for the close and Market Access owns contracting.
• Gross-to-Net Accounting & Analysis:
  • Own the monthly and quarterly gross-to-net accrual and reserve process end-to-end, including distribution and title fees, specialty pharmacy fees, prompt-pay discounts, Medicaid rebates, 340B, FSS/VA pricing, chargebacks, and other revenue deductions.
  • Establish and maintain accrual rate methodology and assumption documentation for a newly launched product with limited claims history.
  • Execute rate true-ups as actual claims and utilization data mature, and explain variances.
  • Build and maintain reserve roll-forwards, reserve-to-payment reconciliations, and rate variance analyses.
  • Serve as the finance owner of third-party government pricing calculations (AMP, Best Price, non-FAMP, Medicaid unit rebate amount, and 340B ceiling price), validating vendor output in partnership with Market Access and supporting executive certification.
  • Monitor payer mix, channel dynamics, and reimbursement developments, translating them into forecast and reserve implications.
• Revenue Forecasting & Analysis:
  • Partner with Commercial Operations & Strategy on the revenue forecast build, from treatment-center-level demand through gross sales to net revenue.
  • Model drivers specific to cell therapy, including authorized treatment center activation and ramp, referral-to-infusion conversion, manufacturing capacity and slot constraints, donor eligibility yield, and vein-to-vein timing.
  • Deliver the monthly latest estimate, quarterly reforecast, annual budget, and long-range plan inputs for revenue and gross-to-net.
  • Produce variance analysis and written commentary for executives and Board reporting.
  • Align demand assumptions with field intelligence and account activation plans in partnership with Commercial and Market Access.
• Commercial Operating Expense Planning:
  • Partner with Commercial, Market Access, Patient Services, and Medical Affairs on budget, latest estimate, and long-range planning for commercial operating expenses.
  • Own budget-versus-actual reporting, accrual review, and variance commentary for commercial functions.
  • Track headcount and program spend against plan, supporting functional leaders in managing their budgets.
• Financial Reporting & Compliance:
  • Partner with Accounting on the revenue close, including journal entries, account reconciliations, flux analysis, and cut-off.
  • Ensure compliance with GAAP, ASC 606, SOX (as applicable), and internal controls.
  • Build and maintain audit-ready documentation and control narratives for gross-to-net and revenue processes.
  • Serve as a primary point of contact for external auditors on gross-to-net methodology and revenue forecasting assumptions.
  • Contribute analysis and peer benchmarking to technical accounting positions on revenue deductions and other ASC 606 matters.
• Systems, Data & Process Scale:
  • Own the flow of finance data from third-party logistics, specialty pharmacy, and distribution partners into forecast and accrual models.
  • Support implementation and maintenance of ERP and planning systems as they relate to revenue and gross-to-net.
  • Drive automation and reporting improvements as transaction volume grows.
  • Support gross-to-net and revenue process design for ex-US markets as they are added.

Requirements

• Bachelor's degree in Finance, Accounting, Economics, or related field.
• 7+ years of progressive biopharmaceutical finance experience, including direct, hands-on ownership of gross-to-net.
• Demonstrated experience building gross-to-net accrual methodology from first principles, rather than solely operating an established revenue management system.
• Strong understanding of US GAAP and ASC 606 as applied to pharmaceutical revenue and revenue deductions.
• Working knowledge of US government pricing programs — Medicaid, 340B, FSS/VA — and how they interact with commercial channel terms.
• Experience partnering across Accounting, Market Access, Commercial, and external auditors.
• Strong analytical and problem-solving skills, with sound judgment in the absence of established precedent.
• High attention to detail and accuracy, with the ability to manage multiple priorities in a fast-paced environment.

Pay

$155,000 - $200,000 a year. The anticipated annual salary range is based on prior experience in the role/industry, education, location, internal equity, and other job-related factors as permitted by law. For remote-based positions, this range may vary based on your local market.

Benefits

• Pre-IPO equity and annual bonus.
• Competitive medical, dental, and vision benefits.
• PTO, 401(k) plan, life and accidental death and disability coverage, and parental leave benefits.
• Subsidized daily lunches and snacks at on-site locations.

About Orca Bio

Orca Bio is a commercial-stage biotechnology company redefining the transplant process by developing next-generation cell therapies with the goal of providing significantly better survival rates with dramatically fewer risks. With our purified, high-precision cell therapies, we aim to replace patients' blood and immune systems with healthy ones and restore their lives.

We are driven by a passion for science and compassion for patients. We act with urgency to ensure our treatments are one day accessible to all who need them. We live by our core values of passion, courage, and integrity. Excellence in our work means the chance to unlock a better quality of life for our patients, and with that comes tremendous responsibility. We innovate on a path that hasn’t been paved, embrace an entrepreneurial spirit, and take calculated risks to achieve our mission. We aren’t afraid to ask “why not” and challenge the status quo. We maintain a start-up culture of camaraderie and leadership by example, regardless of title.

We’re proud to be an equal opportunity employer, and recognize that celebrating our differences creates stronger, lasting solutions that better serve our team, our patients, and their healthcare providers.