Jobs · Engineering · Pennsylvania

Senior Manager, AI and Data Science

Madrigal Pharmaceuticals · Conshohocken, PA · 1 wk ago
Engineering$163k–$200k/yrFull-time

Key Responsibilities

  • Build and operate production AI agents and orchestration workflows using modern agentic frameworks such as LangGraph and deepagents.
  • Design modular, reusable components for reasoning, retrieval, tool integration (including MCP), and workflow automation.
  • Partner with the Agentic UI team to deliver seamless, end-to-end products.
  • Own and optimize the retrieval stack, including vector and hybrid search, embeddings, chunking, and reranking.
  • Build evaluation and regression safeguards for LLM outputs, with particular attention to citation faithfulness and groundedness.
  • Design and deploy machine learning on real-world evidence (claims, EHR, registry), HEOR, and field-medical data to surface Medical Affairs insights.
  • Automate and scale data-ingestion pipelines into AI/ML-ready data on platforms such as Databricks.
  • Own deployment, monitoring, and observability (for example, using LangSmith) for the systems you ship.
  • Cross-Functional Engagement & Governance: Translate complex AI concepts into clear, actionable insights for technical and non-technical Medical Affairs partners. Align AI initiatives with enterprise governance, privacy, and PHI and compliance expectations.

Qualifications

  • A demonstrated record of scientific rigor: either a Ph.D. in a quantitative or medical-adjacent field with first-author publications, or a strong engineering background paired with peer-reviewed research at top venues (for example, NeurIPS, ICML, ICLR, or ML4H).
  • 7+ years of applied machine learning or data science, including 3+ years shipping ML or AI systems to production.
  • 1+ year of hands-on agentic AI development using modern frameworks (for example, LangGraph, deepagents, or LangSmith).
  • Strong RAG and retrieval engineering, including vector and hybrid search, embeddings, and reranking, with the ability to evaluate groundedness and citation accuracy.
  • Applied ML on real-world or patient-level data (claims, EHR, registry), including feature engineering.
  • Experience with production reliability, data access and authentication, and handling sensitive (PHI) data.
  • Strong communication skills and the ability to collaborate across scientific, technical, and business teams.
  • Experience in Healthcare or Life Sciences.

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