Senior Director, Toxicology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, including daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, currently in clinical development.

About the role

We are seeking an experienced senior toxicologist to join our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department. This role combines scientific excellence with strategic leadership, working in close collaboration with Research and Development colleagues on new and ongoing portfolio projects. You will provide toxicology leadership from early research through all stages of clinical development, ensuring safety assessments enable informed development decisions and global regulatory filings.

Responsibilities

• Lead nonclinical safety strategy for multiple drug development programs spanning both small molecules and biologics.
• Serve as the toxicology representative on cross-functional Research and Development project teams, providing scientific guidance and influencing development strategy.
• Design, oversee, interpret, and communicate toxicology studies that support candidate selection, IND-enabling activities, and regulatory submissions.
• Author and review regulatory documents and ensure compliance with GLP, ICH, and global regulatory requirements.
• Provide expert interpretation of toxicology data within the context of current scientific approaches, project objectives, and benefit-risk assessment.
• Lead nonclinical development sub-teams, mentor colleagues, and contribute to departmental strategy and process improvements.
• Collaborate with the investigative toxicology team to drive mechanistic studies for target-, pathway-, or off-target toxicities using in vitro and in vivo studies, including emerging new approach methodologies (NAMs) such as cell- and organoid-based assays and advanced imaging analyses.
• Drive innovation, solve complex scientific problems, and effectively manage multiple programs in a fast-paced environment.

Requirements

• PhD in Toxicology or a related discipline with 10+ years, or M.S. degree with 15+ years, of relevant experience in the biopharmaceutical industry; DABT certification is desirable.
• Deep expertise in nonclinical safety assessment for small molecules and other modalities.
• Strong understanding of toxicology study design, GLPs, global regulatory requirements, with experience interacting with global regulatory authorities.
• Proven ability to lead cross-functional teams, influence strategy, and communicate effectively across scientific disciplines to resolve complex safety questions and support project decision-making.
• Strong scientific background and scientific aptitude with excellent critical thinking skills.

Preferred Skills

• Expertise in integrating mechanistic, translational, and biomarker-based safety assessments into nonclinical development programs.
• Familiarity with impurity risk assessment, product quality, occupational and/or environmental toxicology, or in silico/computational toxicology.

Pay

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $244,000 - $305,000 USD. The range displayed is intended for individuals working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Benefits

In addition to competitive cash compensation, Revolution Medicines offers robust equity awards, strong benefits, and significant learning and development opportunities.