Senior Director, Statistical Programming

About the role

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radioconjugates (BRCs) and imaging agents; zelenectride pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle® technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit bicycletherapeutics.com.

Responsibilities

• Provide strategic and technical leadership for the statistical programming function, driving the delivery of high-quality data and analysis for Bicycle's clinical portfolio.
• Ensure operational excellence across all programming activities, serving as a key strategic partner to Biostatistics and Clinical Development, and leading and mentoring a team of programmers to support the successful execution of our clinical trials and regulatory submissions.
• Strategically lead the statistical programming function, defining and executing the long-term vision and strategy, including resource planning, technology adoption, and talent development.
• Drive the strategy for functional excellence by developing, implementing, and optimizing global Standard Operating Procedures (SOPs), tools, and innovative workflows to enhance efficiency and quality.
• Oversee the strategic selection and governance of CROs and external vendors, ensuring a harmonized approach to programming and holding partners accountable for high-quality, timely deliverables.
• Ensure all statistical programming activities and documentation are inspection-ready, providing senior oversight for data integrity and demonstrating compliance with ICH/GCP guidelines.
• Lead, coach, and mentor your team, investing in their professional growth and fostering a culture of high performance and psychological safety.
• Set clear goals and strategic priorities for your team, ensuring their work is directly aligned with departmental and organizational objectives.
• Champion the Bicycle Values in all that you do, acting as a role model and embedding a culture of collaboration, accountability, and innovation within your team.

Qualifications

• Demonstrated deep expertise in statistical programming gained through significant and progressive experience in a biotech or pharmaceutical setting.
• Proven track record of leading the programming strategy for clinical development programs, preferably within oncology.
• Expert-level knowledge of SAS programming and CDISC data standards (SDTM/ADaM), with extensive experience preparing data for regulatory submissions (e.g., NDA/BLA).
• Substantial experience in managing CROs and external vendors, including technical oversight, governance, and relationship management.
• Proven leadership experience, with the ability to mentor programmers, set strategic direction for a team, and influence cross-functional partners.

Additional Information

• 401(k) plan with a 4% Company match and immediate vesting
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• Employee assistance program (EAP)
• Time off (eligibility to accrue up to 23 paid time off days per full year worked, the option to buy up to 5 additional days & 10 company nominated holidays)
• 10 Company holidays
• Competitive reward including annual company bonus
• Employee recognition schemes
• Enhanced parental leave policies
• Flexible working environment
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Career progression opportunities
• Professional development and training opportunities
• Flexible working environment
• Company culture and values
• Work-life balance initiatives
• Employee benefits and perks
• Company history and mission
• Company vision and goals
• Company commitment to diversity and inclusion
• Company commitment to employee well-being
• Company commitment to sustainability
• Company commitment to ethical business practices
• Company commitment to innovation and research
• Company commitment to patient-centered care
• Company commitment to community engagement
• Company commitment to environmental stewardship
• Company commitment to social responsibility
• Company commitment to corporate citizenship
• Company commitment to transparency and accountability
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