Senior Director, Real World Evidence Generation

About the Role

The Senior Director, Real World Evidence (RWE) leads the strategic design and execution of real-world data and evidence generation initiatives that support clinical value, market access, and lifecycle management goals. This individual is accountable for building a robust, compliant RWE agenda within the Evidence Generation team that complements clinical trial evidence across indications. The Senior Director partners closely with R&D, Market Access, and the Global Medical Leads to ensure evidence generation is scientifically rigorous and strategically relevant, and manages a team of RWE scientists responsible for translating real-world data into decision-ready insights.

Responsibilities

• Integrated evidence strategy
  • Co-own the Integrated Evidence Generation Plan (iEGP) across all Dompé indications — NAION, NK/PCED, AKC, oGVHD, and neurology pipeline — ensuring evidence priorities are strategically sequenced to support regulatory, payer, and scientific exchange goals.
  • Partner with Global Medical Leads to translate indication-specific medical strategy into evidence priorities, identifying gaps between current data and the evidence needed for launch readiness, label expansion, or lifecycle management.
  • Represent Evidence Generation in cross-functional governance forums including the Integrated Evidence Plan review, and serve as the senior MA voice in discussions with Clinical Development on trial-adjacent evidence needs.
  • Maintain a forward-looking view of the competitive evidence landscape across indications, ensuring Dompé's evidence plan addresses emerging gaps or challenges.
• RWE strategy and study design
  • Provide strategic direction and senior oversight to the Associate Director of RWE & Epidemiology, ensuring the real-world evidence and epidemiology program is aligned to the iEGP and addresses payer, regulatory, and scientific exchange needs.
  • Partner with Market Access and Commercial on the evidence requirements for HTA submissions and payer-facing evidence packages, ensuring the RWE and epidemiology program produces outputs that are credible, timely, and decision-grade.
  • Represent RWE and epidemiology evidence in cross-functional medical strategy discussions, ensuring real-world data complements and contextualizes clinical trial data in the scientific narrative.
• Cross-functional alignment
  • Partner with R&D, Market Access, and Global Medical Leads to align evidence with payer and clinical needs.
  • Support translation of RWE findings into publications, dossiers, and internal strategic recommendations.
  • Manage relationships with external research partners, academic collaborators, and data vendors.
• Team and budget management
  • Build, mentor, and manage a team of RWE scientists and associate directors.
  • Manage RWE budget and prioritization across therapeutic areas.
  • Establish study prioritization criteria in partnership with senior Medical Affairs leadership.

Requirements

• Required
  • PhD, PharmD, or equivalent in epidemiology, health outcomes, biostatistics, or related field.
  • 10+ years of experience in real-world evidence, epidemiology, or outcomes research.
  • Demonstrated experience designing and executing observational research.
  • Strong understanding of real-world data sources (claims, EHR, registries).
  • Experience presenting evidence to internal and external stakeholders.
• Preferred
  • Experience in ophthalmology, immunology, or specialty care therapeutic areas.
  • Publication record in peer-reviewed real-world evidence studies.
  • Experience building an RWE function within a growing Medical Affairs organization.

Skills

• Methodological rigor: designs observational studies that hold up to scientific and regulatory scrutiny.
• Strategic prioritization: allocates limited evidence-generation resources to the studies with the highest clinical and business value.
• Stakeholder translation: converts complex real-world data into insights that HEOR, Market Access, and clinical teams can act on.
• External partnership: builds durable relationships with academic and data-vendor collaborators.
• Team development: coaches RWE scientists toward greater independence and strategic ownership.

Benefits

• Comprehensive medical benefits.
• Generous vacation and holiday time off.
• Competitive 401(K) matching.

Pay

Base Salary: $285,000 - $370,000 a year.