Senior Director, Project Management

About the role

IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward. For more information, please see www.ideayabio.com. Location: South San Francisco, CA. Reporting to: Vice President, Program & Portfolio Management.

Responsibilities

• Serve as Project Manager for IDE892, owning the overall program strategy in partnership with the Clinical Lead and Head of Research
• Integrate scientific, clinical, regulatory, and commercial perspectives into a coherent Development Plan and Target Product Profile (TPP)
• Lead program-level scenario planning, portfolio prioritization discussions, and trade-off analyses for Senior Leadership and the Board
• Serve as a key point of contact for the Roche collaboration on IDE892, supporting Joint Steering Committee preparation and cross-company alignment
• Anticipate strategic inflection points, including: combination selection, indication prioritization, registrational entry
• Own and maintain the IDE892 integrated program timeline, critical path, milestone tracking, and risk register
• Lead cross-functional Program Team meetings; drive decision-making, document outcomes, and ensure accountability
• Partner with Clinical Operations to oversee study execution across IDE892-001 cohorts, including RAS combination arms and expansion into PDAC and NSCLC
• Manage program budget in partnership with Finance; ensure accurate forecasting and resource alignment
• Coordinate cross-functional readiness for IND amendments, regulatory interactions, and data readouts
• Proactively identify program risks across scientific, operational, regulatory, and partnership dimensions
• Facilitate rapid cross-functional risk assessment and drive contingency planning
• Escalate critical issues to Senior Leadership with clarity and recommended paths forward
• Support management of the