Senior Director, Pharmacokinetics

We are seeking an accomplished and highly collaborative Senior Director to provide scientific, operational, portfolio, and people leadership within the Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) organization. This role supports discovery programs across multiple therapeutic areas and modalities, shaping and executing fit-for-purpose bioanalytical strategies to enable high-quality, timely data packages for molecular design, candidate selection, translational interpretation, regulatory readiness, and portfolio decision-making. The Senior Director may also represent PDMB in discovery and/or development programs.

About the role

The successful candidate will serve as a senior scientific and operational leader for bioanalytical activities across a portfolio of biologics, small molecules, conjugates, and novel modality programs. This individual will directly manage and develop bioanalytical leaders, laboratory scientists, and program representatives, ensuring high-impact scientific contributions, clear decision-enabling bioanalytical interpretation, and effective project-team representation. The role requires close partnership with internal and external organizations to drive integrated, data-driven pipeline support.

Key focus areas include strengthening scientific rigor in bioanalysis, harmonizing workflows, driving operational excellence through automation and innovative technologies, and fostering a high-performing, inclusive, and collaborative team culture.

Responsibilities

• Provide scientific and portfolio leadership for bioanalytical strategy across discovery programs, ensuring fit-for-purpose assay execution, data quality, compliance, and decision-making impact across biologics, conjugates, peptides, small molecules, and emerging modalities.
• Drive operational excellence through workflow optimization, resource and capacity planning, automation, digital tools, data systems, and continuous improvement of bioanalytical processes.
• Promote harmonization and knowledge sharing across bioanalytical teams, sites, and external partners to improve consistency, flexibility, and responsiveness to changing portfolio needs.
• Monitor external scientific, technology, and regulatory trends in bioanalysis and related disciplines; champion evaluation and implementation of new methodologies and best practices.
• Manage a team of DMPK team representatives and bioanalytical leaders/scientists, setting clear scientific expectations and enabling effective prioritization, execution, and career development.
• Represent PDMB on cross-functional discovery and development teams, integrating bioanalytical, ADME, PK/PD, translational, and regulatory perspectives to guide program decisions.
• Ensure PDMB deliverables support molecular design, lead optimization, candidate selection, nonclinical-to-clinical translation, first-in-human enablement, regulatory submissions, and clinical development planning.
• Serve as a scientific advisor or principal investigator for programs, platform initiatives, or cross-functional scientific workstreams.
• Build and maintain effective partnerships with discovery, development, translational, clinical, regulatory, and external collaborators to enable integrated pipeline support.
• Review, author, and present scientific documents, regulatory sections, technical reports, portfolio updates, and decision-making materials for internal and external stakeholders.
• Foster a culture of innovation, accountability, collaboration, inclusion, safety, quality, and compliance.

Requirements

Master's (with 15+ years) or Ph.D. (with 12+ years) in pharmacokinetics, pharmaceutical sciences, bioanalytical chemistry, analytical chemistry, biochemistry, biology, pharmacology, immunology, bioengineering, or a related scientific discipline with significant experience in bioanalytical sciences, DMPK, drug discovery, and development.

Skills

• Demonstrated scientific and operational leadership in bioanalysis, including assay strategy, method development, validation or qualification, sample analysis, data interpretation, and reporting.
• Strong understanding of bioanalytical approaches relevant to biologics, conjugates, peptides, small molecules, and novel therapeutic modalities.
• Proven experience participating in cross-functional discovery and development program teams.
• Ability to integrate bioanalytical, ADME, PK, PK/PD, translational, toxicology, clinical pharmacology, and regulatory considerations to support program decisions.
• Demonstrated ability to manage a portfolio of programs through early strategy formation, prioritizing resources, aligning deliverables with milestones, identifying risks, and ensuring high-quality scientific execution.
• Proven people leadership experience, including management, mentoring, talent development, performance management, and building high-performing scientific teams.
• Ability to lead through change, shape organizational capabilities, and develop future scientific and people leaders.
• Excellent written and verbal communication skills, with the ability to present complex scientific and operational topics clearly to technical, cross-functional, and senior leadership audiences.
• Strong collaboration and influencing skills, with demonstrated ability to build effective partnerships across functions, sites, and external organizations.
• Commitment to quality, safety, compliance, scientific rigor, operational excellence, and inclusive leadership.

Preferred Skills

• Ability to modernize workflows through automation, digital tools, data systems, assay harmonization, process improvement, or innovative bioanalytical technologies.
• Experience serving as a scientific representative or functional leader accountable for cross-function and/or cross-site collaboration.
• Familiarity with translational PK/PD, exposure-response, human dose projection, biomarker strategy, biodistribution assessment, immunogenicity risk assessment, or model-informed drug development.
• Experience supporting or leading programs involving drug conjugates, multispecific biologics, peptides, or other complex and emerging modalities.
• Working knowledge of cell-based assays, biophysical or biochemical characterization.
• Track record of scientific visibility through publications, conference presentations, external collaborations, consortia participation, or cross-industry engagement.

Benefits

• Comprehensive medical, dental, vision, and other insurance benefits for employee and family.
• Retirement benefits, including 401(k).
• Paid holidays, vacation, compassionate, and sick days.
• Annual bonus and long-term incentive eligibility (if applicable).

Pay

The salary range for this role is $194,100.00 - $305,600.00. An employee’s position within the salary range will be based on relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

Schedule

• Regular, full-time position.
• 10% travel required.
• First-shift (day) schedule.
• Domestic and international relocation assistance available.
• Visa sponsorship available.