Senior Director of Clinical Science - Lung

Reporting to the Executive Director – Lung, Head and Neck, and Gastrointestinal, or to the Head of Clinical Science Oncology, this role provides strategic Clinical Science leadership across the lung disease area, spanning multiple studies, programs, and assets.

Responsibilities

• Provide strategic Clinical Science leadership across the lung disease area, including multiple studies, programs, and assets.
• Contribute to disease area strategy by applying deep therapeutic expertise to guide Clinical Science approaches, support development planning, and promote consistency in scientific standards, medical data review practices, and decision-making across the portfolio.
• Partner with Section Heads, Asset Leads, Program Development Team Leads, and cross-functional development team members to support study planning, data interpretation, issue resolution, and broader program decisions.
• Apply expert knowledge of lung cancer, including disease biology, current and emerging treatment landscape, relevant clinical endpoints, and key scientific considerations to inform study planning, data interpretation, and issue resolution.
• Support cross-study and cross-asset integration of scientific insights to inform development decisions within the lung portfolio.
• Lead efforts to standardize Clinical Science approaches, including medical data review practices, data interpretation principles, and key deliverables.
• Promote consistency in Clinical Science activities across studies and programs while allowing for program-specific needs.
• Establish and maintain standards, expectations, and leading practices for Clinical Science work within the lung portfolio.
• Support alignment across assets on important disease area considerations, such as endpoint interpretation, patient population considerations, safety topics, and emerging scientific issues.
• Advocate for implementation of innovative approaches, including visual analytics, centralized data review, AI-enabled workflows, and other technologies to improve quality and efficiency.
• Provide senior scientific guidance across assigned studies and programs to ensure high-quality and consistent Clinical Science input.
• Guide interpretation of clinical data across studies, cohorts, and assets to support broader understanding of trends, opportunities, risks, and program implications.
• Support identification and evaluation of important clinical, scientific, and data-related issues, ensuring they are appropriately framed for cross-functional and governance discussions.
• Contribute scientific perspective to protocol development, protocol amendments, study design considerations, endpoint selection, eligibility criteria, biomarker strategy discussions, and other development planning activities.
• Serve as a Clinical Science subject matter resource for lung cancer across study teams and partner functions.
• Contribute Clinical Science perspective to portfolio discussions, governance reviews, and senior leadership meetings within the lung disease area.
• Support preparation of clinical and scientific content for governance discussions, program reviews, and senior management communications.
• Present cross-study insights, scientific assessments, and key issues to cross-functional leaders and governance bodies.
• Ensure portfolio and governance discussions are informed by sound scientific judgment and clinically meaningful interpretation of available data.
• Translate portfolio priorities into Clinical Science strategies, capabilities, and resource plans.
• Provide direct management for Directors, Principal Scientists, and Clinical Scientists, setting clear expectations for scientific quality, strategic thinking, collaboration, and effective communication.
• Support development of Clinical Science talent through coaching, mentoring, feedback, and creation of development opportunities.
• Promote consistency in role expectations and ways of working across Clinical Scientists supporting the lung portfolio.
• Foster a culture of accountability, inclusion, continuous learning, and strong team performance.
• Partner closely with Clinical Operations, Regulatory Affairs, Biostatistics, Data Management, Drug Safety and Pharmacovigilance, Translational Medicine, Medical Affairs, and other key partner functions.
• Represent Clinical Science in cross-functional planning, program discussions, and strategic decision-making forums.
• Facilitate alignment across studies, programs, and functions to support consistent scientific approaches and effective portfolio execution.
• Support clear communication of clinical and scientific issues to relevant stakeholders and leadership teams.
• Ensure Clinical Science activities are conducted in accordance with applicable regulatory requirements, company policies, and established procedures.
• Support inspection readiness and appropriate documentation of Clinical Science contributions.
• Identify opportunities to improve the quality, consistency, and effectiveness of Clinical Science work across the lung disease area.
• Maintain awareness of relevant scientific, clinical, and regulatory developments in lung cancer to inform disease area strategy and Clinical Science practices.

Requirements

• Advanced scientific or healthcare degree (PhD, PharmD) with at least 7 years of lung oncology drug development experience, or Master’s Degree in life sciences with 12 years of lung oncology drug development experience.
• Significant experience in Clinical Development, Clinical Science, oncology development, or a related function within the pharmaceutical or biotechnology industry.
• Demonstrated experience providing Clinical Science leadership across multiple studies, programs, or assets.
• Deep therapeutic area expertise in lung cancer, including strong understanding of disease biology, current and emerging treatment landscape, clinically relevant endpoints, and key scientific considerations affecting development.
• Strong understanding of clinical trial design, clinical development strategy, clinical data review, and interpretation of oncology data.
• Experience contributing to disease area strategy, portfolio discussions, or cross-program planning.
• Experience contributing to regulatory submissions, safety reviews, or health authority interactions.
• Experience working effectively in cross-functional teams within a matrix environment.
• Demonstrated ability to integrate information across studies and programs to support scientific and business decisions.
• Excellent communication, influence, and executive presentation skills.
• Demonstrated people leadership experience, including management, coaching, and development of scientific staff.

Skills

• Required: Change Agility, Clinical Development, Clinical Oncology, Clinical Reporting, Clinical Research, Clinical Sciences, Clinical Study Management, Clinical Trial Management, Medical Sciences, Oncology, People Leadership.
• Preferred: Experience with current employees or contingent workers hiring processes.

Pay

The salary range for this role is $190,800.00 - $300,300.00. An employee’s position within the salary range will be based on factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

• Comprehensive medical, dental, vision healthcare, and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

Schedule

Travel requirements: 0-25%.