Senior Director, GI & Inflammatory Disease Research

Responsibilities

• Lead disease biology strategy for discovery and preclinical-stage programs, with emphasis on protease, immune-mediated, and GI diseases.
• Develop mechanistic understanding of disease pathways and translate biological insights into therapeutic opportunities.
• Establish and oversee translational disease biology plans supporting progression of assets from discovery through clinical proof-of-concept.
• Evaluate emerging biology, competitive intelligence, and therapeutic opportunities within protease and GI disease and inflammatory pathways.
• Partner with DMPK, toxicology, bioanalytics, and clinical pharmacology teams to establish robust development strategies.
• Support first-in-human, dose-escalation, and proof-of-concept studies through integration of nonclinical and emerging clinical data.
• Lead multidisciplinary project teams and influence portfolio strategy.
• Collaborate with Clinical Development, CMC, Regulatory, and Program Leadership to ensure seamless translation from research to clinical development.
• Present program recommendations and scientific strategy to executive leadership, governance committees, partners, and external stakeholders.
• Mentor and develop a high-performing disease biology team.
• Foster a culture of scientific excellence, innovation, accountability, and collaboration.

Qualifications

• PhD, MD, or MD/PhD in Immunology, Cell Biology, Molecular Biology, Pharmacology, Gastroenterology, or a related discipline.
• 15+ years of biotechnology and/or pharmaceutical industry experience, including significant leadership responsibilities.
• Demonstrated success advancing therapeutic programs from discovery through IND and into clinical development.
• Extensive experience supporting development of biologic therapeutics.
• Experience in inflammatory, autoimmune, or GI disease biology is highly preferred.
• Proven track record of scientific publications, external presentations, patents, and/or successful development milestones.
• Experience working in highly matrixed environments and leading cross-functional teams.