Senior Director, Clinical Pharmacology & Pharmacometrics, Research Business Insights & Technology

Role Overview

Bristol Myers Squibb is seeking a strategic, scientifically grounded leader to serve as the Senior Director for Clinical Pharmacology & Pharmacometrics. This leader will partner deeply with Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, and Translational Medicine stakeholders to deliver the applications, modeling environments, workflow automation, and governed operational capabilities that support CPP work end to end—from quantitative preclinical-to-clinical bridging through clinical PK/PD, dose and regimen decisions, and submission-support outputs.

Sub-Areas in Scope

• Pharmacometric applications, including population PK, PK/PD, exposure-response, dose optimization, and model-informed decision support
• PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows
• Clinical PK/PD systems and operational tooling that support end-to-end CPP execution
• CPAR, Quarto-based or similar reporting automation, and submission-support workflows for quantitative regulatory deliverables
• Quantitative translational workflows that bridge preclinical and clinical evidence in support of CPP decision-making
• Workflow governance, audit trails, validation support, access controls, and inspection-ready operational practices for regulated quantitative environments
• AI-enabled and advanced analytics capabilities that improve CPP workflow efficiency, simulation, review, reporting, and knowledge reuse

Mission & Impact

Provide a scalable application and workflow backbone for CPP across preclinical-to-clinical translation, clinical PK/PD, dose selection, exposure-response, and model-informed development decisions
Improve the speed, quality, reproducibility, traceability, and inspection-readiness of pharmacometrics and clinical pharmacology workflows
Strengthen regulatory submissions through robust reporting, reusable quantitative evidence generation, and auditable outputs that support documents such as clinical pharmacology summaries and model-based appendices
Enable governed automation of priority CPP workflows, including reporting, simulation, execution, review, and knowledge reuse
Create a durable technology foundation for end-to-end CPP that can scale with pipeline demand and integrate cleanly across the broader Research and Development ecosystem

Key Responsibilities

• Serve as the single BI&T point of accountability for CPP technology, applications, workflows, and support services end to end
• Partner across Research and Development to integrate CPP workflows with the scientific, data, and operational capabilities required for model-informed drug development
• Own clinical pharmacology and pharmacometrics applications, modeling environments, reporting workflows, and operational support for core CPP use cases
• Ensure operational excellence, reliability, governance, and continuous improvement across modeling environments, clinical PK/PD systems, reporting workflows, and submission-support applications
• Lead automation of priority CPP workflows, including model execution, reporting, simulation, traceability, review, and evidence reuse
• Support quantitative regulatory deliverables through fit-for-purpose tooling, reproducible workflows, and inspection-ready practices
• Partner with Unified Lab & Experimental Platforms, Target & Disease Biology, and In-Vivo & Non-Clinical Pharmacology where translational science, lab systems, diagnostics, biomarker workflows, or bioanalytical capabilities intersect with CPP needs
• Partner with the R&D Data organization on underlying data-product strategy, integration, and fit-for-purpose data access
• Lead and grow a team of scientific technologists, product leaders, and specialized engineers aligned to this domain

Required Experience & Qualifications

• Ph.D. in Pharmacometrics, Clinical Pharmacology, Pharmaceutical Sciences, Biostatistics, or related quantitative field
• 12+ years in pharmaceutical R&D with deep clinical pharmacology, pharmacometrics, and model-informed drug development experience
• Proven experience implementing or leading CPP applications, PBPK and QSP environments, clinical PK/PD systems, or quantitative workflow automation
• Demonstrated experience supporting regulatory submissions, quantitative reporting, and governed workflows in Development-facing settings
• Experience applying AI/ML or advanced automation to quantitative modeling, reporting, or regulated scientific workflows is preferred
• Director or Senior Director-level leadership experience; experience building and scaling a specialized scientific technology team is a strong differentiator

Critical Capabilities

• Scientific Depth in Clinical Pharmacology and Pharmacometrics — Deep credibility with quantitative scientists and domain leaders across CPP
• Strategic Partnership — Translates scientific and Development needs into practical, integrated technology and workflow solutions
• Operational Leadership — Builds reliable, scalable, inspection-ready environments and support models for critical quantitative workflows
• Regulatory Translation Capability — Understands how quantitative evidence is prepared, reported, reviewed, and used in regulatory settings

Critical Capabilities (continued)

• Leadership & Change Attributes — Strong partnership with senior scientific, clinical, and regulatory leaders
• Comfort operating with regulatory and global Development stakeholders
• Ability to recruit, develop, and retain highly specialized quantitative talent in a competitive market
• Experience navigating matrixed organizations and building credibility quickly
• Commitment to building a collaborative, high-performing culture in a growing team

Why This Role Matters

This role is central to building the next generation of CPP capabilities, ensuring that scientists have the tools, automation, and integrated workflows needed to improve quality, reuse, and accountability across the pipeline.