Senior Director, Biotherapeutics

Key Responsibilities

• Manage and mentor internal protein scientists and protein engineers
• Build and focus teams in a capital-efficient manner to support current and future pipeline needs
• Foster strong collaborative interactions between biotherapeutics teams and teams supporting AI/ML protein design and screening, oligonucleotide therapeutic discovery, and pharmacology
• Support the discovery and characterization of shuttled therapeutics via 1-2 matrix project teams, serving as biotherapeutics lead or project lead
• Map out critical path activities through IND-enabling studies and ensure key activities are resourced and executed efficiently
• Engage with consultants, contractors and CROs/CDMOs to efficiently build expertise and capabilities that accelerate program progression
• Set and implement strategy for developability assessment and early-stage de-risking
• Prepare and present data packages for partnering discussions and investor presentations

Strategic Leadership

• Contribute to high-level strategy and key objectives for discovery and development of shuttled therapeutics
• Establish development candidate nomination criteria for novel biotherapeutics with particular focus on developability metrics
• Identify and outline opportunities for backup molecule discovery and selection

Qualifications

• Extensive experience in biotherapeutics across a range of protein modalities
• Proven track record engineering antibodies for clinical development
• Deep knowledge of state-of-the-art protein engineering approaches
• Experience with protein expression systems, purification methods, and characterization including developability assays
• Prior experience liaising with CDMOs

Preferred Qualifications

• Expertise with novel modalities and complex formats, including ADCs, tissue-targeted therapeutics, and bispecific antibodies
• Understanding of high-throughput screening and bioanalytical technologies
• Experience with generative AI models for protein and/or oligonucleotide design

Pay

Base Salary Range: $240,000-340,000

Schedule

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

Benefits

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Company Information

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Equal Opportunity Employer

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.