Senior Director, ADME

About the role

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. The Senior Director, ADME will provide technical leadership and execution for ADME activities supporting nonclinical and clinical development programs.

Responsibilities

• Serve as the ADME subject matter expert, with deep expertise in metabolism
• Define and execute ADME strategies in collaboration with functional area leads
• Design, oversee, and interpret nonclinical ADME studies (in vitro and in vivo)
• Manage CROs, including vendor selection, study design, protocol development, and report review
• Ensure ADME data are scientifically sound and aligned with regulatory expectations
• Support clinical development through ADME input, including DDI risk assessment, PBPK modeling, and human ADME (mass balance) study design and interpretation
• Integrate nonclinical and emerging clinical PK data to inform ADME strategy and study design
• Author and review ADME sections of regulatory submissions (IND/CTA, NDA) and support regulatory interactions

Qualifications

• Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related discipline (or equivalent experience)
• 15+ years of ADME experience in pharmaceutical or biotechnology drug development
• Experience supporting both nonclinical and clinical programs
• Deep expertise in drug metabolism (required)
• Working knowledge of transporters and broader ADME sciences
• Strong experience designing and interpreting ADME studies
• Experience with PBPK modeling and human ADME (mass balance) studies preferred

Core Competencies

• Strong scientific judgment and attention to detail
• Hands-on, execution-focused approach
• Effective communicator within technical and cross-functional teams
• Ability to operate in a fast-paced, dynamic environment

Pay

A good faith estimate of the current pay scale for this position, applicable to all candidates, is $256,000 - $313,000 per year. We comply with all applicable minimum wage laws.

Schedule

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com.