Senior Clinical Scientist, ECD
Position Summary
We are seeking a Senior Clinical Scientist to lead execution of key components of clinical development for our early cancer detection (ECD) program. This role is central to leading study execution, clinical data review, study design, and generation of scientific insights across multiple studies.
Primary Responsibilities
Lead Clinical Development & Study Design
- Lead substantial aspects of ECD clinical studies or multiple studies
- Drive study design, including objectives, endpoints, eligibility criteria, and schedules of assessments
- Author and review protocols, ICFs, CRFs, and study documents
- Contribute meaningfully to clinical development strategy and study-level decision-making
- Contribute to process improvements and development of best practices
Drive Data Review & Strategic Insight
- Lead medical and clinical data review to ensure data quality and integrity
- Analyze complex datasets to identify trends, risks, and opportunities
- Translate data into actionable insights that inform study and program decisions
- Partner with safety and medical teams on signal detection and escalation
Lead Cross-Functional Execution
- Own day-to-day clinical science responsibilities across assigned studies
- Drive resolution of study-level issues, risks, and operational challenges
- Partner closely with Clinical Operations, Medical Affairs, Regulatory, and Biostatistics to monitor study conduct, data quality, enrollment performance, and milestone delivery
- Make study-level decisions and recommendations in ambiguous situations with limited oversight
- Represent Clinical Science in internal and external forums (e.g., investigators, KOLs)
Drive Study Performance & Program Value
- Prioritize activities across studies to ensure quality, timelines, and program impact
- Actively monitor study conduct, enrollment performance, protocol compliance, and clinical data quality across studies
- Identify operational risks early and implement corrective actions to maintain study timelines and quality
Advance Scientific Communication
- Lead development of abstracts, presentations, and manuscripts
- Translate clinical and statistical results into clear scientific narratives
- Support internal decision-making and external evidence generation
Qualifications
Advanced degree (PhD, PharmD, MD, or equivalent; MS, MPH, RN with experience considered)
6+ years of experience in clinical research, clinical science, or related field
Strong experience leading clinical studies and contributing to study design
Demonstrated experience leading and executing clinical studies, including clinical data review, study-level decision making, issue management, and cross-functional coordination
Preferred Qualifications
Experience in oncology, diagnostics, or early cancer detection
Experience working across multiple studies or programs
Track record of scientific publications and conference presentations
Knowledge, Skills, and Abilities
Ability to lead complex clinical studies or multiple workstreams independently
Ability to balance scientific rigor with pragmatic decision-making in a fast-paced environment
Demonstrated ownership mindset with willingness to operate outside traditional functional boundaries when needed to advance study and program goals
Strong analytical skills with ability to synthesize complex data into decisions
Effective influencer across functions and senior stakeholders
Excellent scientific communication skills
Location
San Carlos, CA or Remote, USA (West Coast or Mountain time zones preferred)
Benefits
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
About the Company
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
Our Opportunity
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.