Senior Biostatistician

The Role We’re looking for an experienced, hands-on Senior Biostatistician for our Boston team. This is a senior individual-contributor role for someone who owns the statistical thinking on a trial end to end, from design and endpoints through specifications, outputs, and interpretation, and who authors the deliverables rather than reviewing what others produce. Generative AI and coding agents are part of everyday statistical work here, and your judgment is what determines whether the resulting analyses are right. Most of your collaboration will be with our AI and software engineers rather than a traditional clinical matrix, working alongside them to bring TriClick™ to bear on real clinical programs. What You’ll Do Author the core statistical deliverables for Phase I-III trials: Statistical Analysis Plans, analysis specifications, TLF shells, and the documentation that carries a study from protocol to final outputsOwn the statistical thinking behind design, endpoints, estimands, analysis methods, missing data, and sensitivity analyses, and defend those choices against regulatory expectationsScrutinize analysis datasets, specifications, outputs, and code, including AI-generated work, for statistical sense, consistency, and traceability before anything shipsUse generative AI and coding agents day to day to write and modify SAS or R code, investigate unfamiliar problems, debug, and iterate toward working analyses, while staying accountable for whether the implementation is correctCollaborate day to day with our AI and software engineers, translating statistical intent into product behavior, pressure-testing what the models and pipelines produce, and covering the ground from SDTM and ADaM through TLF production rather than working inside a statistician siloBring frontline statistical judgment into TriClick™ by using it on live clinical programs What You’ll Need Substantial hands-on clinical development experience as a trial statistician, with an advanced degree in a quantitative field and the demonstrated independence to reason through design, endpoints, estimands, methods, missing data, sensitivity analyses, and interpretationPersonal authorship of major statistical deliverables (SAPs, analysis specifications, TLF shells, and related core documentation), with a working understanding of how protocol, SAP, analysis datasets and specifications, and final outputs fit together. This is a must-have; having reviewed or approved work produced by others is not a substituteA critical, skeptical mindset: you question assumptions, chase inconsistencies, scrutinize outputs, and recognize when a result does not make statistical sense. You don’t trust code, software output, or AI-generated work simply because it ranComfortable working with statistical code in SAS and/or R using modern AI-assisted development tools, with the statistical judgment needed to inspect, modify, debug, and validate the resulting analyses. AI fluency is a requirement at Hill, not a nice-to-have, though we are not looking for an ML engineer or AI architectPractical working knowledge of CDISC, particularly ADaM, with familiarity with SDTM and the broader clinical data and statistical programming workflowSound understanding of regulatory expectations (FDA, EMA) for statistical analyses and deliverables, which matters more to us than having personally led a submissionHigh autonomy and a can-do instinct: faced with an unfamiliar statistical, data, or technical problem, you investigate it, form an informed view, and work toward a practical solution rather than treating it as someone else’s remitA clear communicator who works effectively with engineers as well as clinical and client stakeholders, moving easily between methodology, specifications, data, outputs, and AI tooling Nice to Have Exposure to NDA/BLA submissions or direct interaction with the FDA or other health authoritiesExperience building, specifying, or shaping statistical software, tooling, or automationExperience in a startup or other small, fast-moving team where scope is set by the problem, not the job title Why Join Hill Research Join a company redefining how biostatistics and clinical trial delivery work through AIWork alongside seasoned scientists and engineers from leading pharma and top tech, with broad scope and real autonomy over how the statistics get doneDirectly shape our core product (TriClick™) and client delivery during rapid growthCompetitive compensation and equity package, with comprehensive benefits This role reports to the Head of Biostatistics.