Senior Bioinformatics Scientist

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About the role

We are seeking a talented and highly motivated Senior Bioinformatics Scientist to support the development of Roche Diagnostics Molecular Assays that have a global impact on patient care. This role requires a broad understanding of assay development across diverse technologies, including NGS, Nanopore sequencing, and PCR. The successful candidate will collaborate closely with bioinformaticians, wet lab scientists, and external customers to design, implement, and maintain internal algorithms and tools for clinical diagnostic assay development.

• Collaborate with multidisciplinary teams of molecular and computational biologists, as well as wet lab scientists, to design, optimize, and troubleshoot advanced high-throughput sequencing assays and workflows for clinical diagnostic applications
• Contribute bioinformatics expertise throughout the assay development lifecycle, including initial sequencing, validation, and production implementation, by developing and maintaining analytical tools and pipelines for processing diagnostic data from tumor, germline, and cell-free DNA samples
• Create, implement, and streamline bioinformatics tools and workflows in partnership with wet lab scientists to enhance assay development efficiency and data quality
• Provide hands-on troubleshooting to ensure data quality, integrity, and accessibility across the diagnostic workflow, while addressing the needs of internal and external stakeholders through scientific and business analyses
• Advocate for best practices in documenting, training, and scaling algorithms, tools, and workflows to ensure reproducibility and scalability
• Communicate project outcomes and team progress across various teams and organizational functions to promote alignment and collaboration

Requirements

Required:

• Bachelor's Degree and 7+ years of experience

Preferred:

• PhD in Bioinformatics, Computational Biology, Statistics, or a related field with 2 years of industry experience in clinical diagnostics or related domain
• Masters degree in Bioinformatics, Computational Biology, Statistics, or a related field with 5 years of industry experience in clinical diagnostics or a related domain

• Expertise in DNA/RNA sequencing data analysis and interpretation
• Strong understanding of molecular biology principles and hands-on familiarity with next-generation sequencing laboratory processes

Skills

• Proficient in programming skills in R and/or Python, with experience working in a distributed Linux environment (Proficiency in C++ or Java is a plus)
• Proficient in creating clear, insightful visualizations of complex biological data, with strong presentation skills
• Skilled in writing and maintaining bioinformatics workflows using workflow management systems such as Snakemake or Nextflow
• Solid understanding of cancer biology and in vitro diagnostics (IVD)

Pay

The expected salary range for this position based on the primary location of California is $102,100 - $167,850. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

Benefits

This position qualifies for the benefits detailed at the link provided below.