Senior Associate Scientist LNP Process Development

Working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, transforming the lives of patients and the careers of those who do it. From optimizing production lines to breakthroughs in cell therapy, you’ll grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. BMS offers a wide variety of competitive benefits, services, and programs that provide resources to pursue goals both at work and in personal life.

Bristol Myers Squibb is on a mission to discover, develop, and deliver innovative medicines that help patients prevail over serious diseases. In October 2025, BMS expanded its RNA medicines capabilities through the acquisition of Orbital Therapeutics, bringing a powerful RNA platform that combines circular and linear RNA engineering, advanced delivery technologies, and AI-driven design. This platform accelerates BMS's efforts to pioneer programmable RNA therapies across immunomodulation, oncology, next-generation vaccines, and protein therapeutics. We are building a world-class LNP Process Development team in Cambridge, MA, focused on cutting-edge RNA delivery science.

About the role

Bristol Myers Squibb is seeking a motivated and detail-oriented Senior Associate Scientist to join our LNP Process Development team in Cambridge, MA. This role focuses on LNP process development, spanning early process development through clinical manufacturing support. It is an excellent opportunity for an early-career scientist to grow within a dynamic, fast-paced environment. The successful candidate will support planning and execution of laboratory studies and contribute to protocols, technical reports, and regulatory documentation under the guidance of senior team members.

Responsibilities

• Execute hands-on laboratory experiments focused on LNP process development and scale-up from bench to pilot scale.
• Design and perform experiments for optimization and characterization of targeted lipid nanoparticles using structured approaches in both upstream and downstream unit operations (i.e., QbD principles, DoE).
• Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early- to late-stage development activities.
• Perform routine analytical testing to assess LNP conjugation, particle size, encapsulation, and concentration.
• Analyze and interpret experimental results, present findings to senior scientists and project teams.
• Collaborate with internal R&D, analytical development, and manufacturing to advance BMS's LNP pipeline.
• Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed.
• Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards.

Requirements

• BS with 2+ years of industry experience, or MS with 0–3+ years of relevant experience, in Chemical Engineering, Biomedical Engineering, Biochemistry, or a related scientific discipline.
• Hands-on experience with LNP formation techniques both at small scale and at large scale.
• Familiarity with analytical tools used to assess LNP quality, including ribogreen for measuring encapsulation efficiency, and DLS for measuring particle size.
• Basic understanding of LNP formation unit operations.
• Strong laboratory fundamentals and attention to detail; comfortable working with bench-top equipment including nanoparticle formation equipment and UF/DF skids.
• Ability to organize and analyze experimental data, identify trends, and clearly communicate results to team members.
• Exposure to GMP principles or cGMP environments is a plus but not required.
• Experience with design of experiments (DoE) or statistical analysis software is a plus.
• Ability to travel internationally up to 10% of the time.

Pay

The starting compensation range for this full-time role in Cambridge, MA is $96,010 - $116,339. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account required skills, job location, work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life Benefits:
  • Paid Time Off for US Exempt Employees: Flexible time off (unlimited, with manager approval), 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico, or Rayzebio employees).
  • Paid Time Off for Phoenix, AZ, Puerto Rico, and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays.
  • Additional time off may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown between Christmas and New Year’s Day.

Eligibility for benefits may vary based on job and location. All global full- and part-time employees actively employed at and paid directly by BMS at the end of the calendar year are eligible for the Global Shutdown.