Senior Associate Scientist, LNP Formulations

Key Responsibilities

• Conduct LNP formulation optimization and characterization
• Support in vitro/in vivo studies by producing LNPs encapsulating siRNAs and/or mRNAs
• Generate analytical data to understand physicochemical parameters of LNPs across various payloads and to support projects in research/development
• Support novel method development of LNP characterization and LNP delivery
• Develop and characterize formulations across diverse therapeutic modalities (e.g., antibody-oligonucleotide conjugates and other emerging modalities)
• Design, plan and perform scientific experiments and contribute to project related scientific activities with some guidance from team members
• Analyze, summarize experimental data, and present scientific findings in the cross-functional teams
• Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols
• Work closely with scientists in Medicinal Chemistry, RNAi biology, and early development teams

Qualifications

• BS/MS in Chemical Engineering, Material Science and Engineering, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 2-4 years of industry experience with a focus on LNP formulation and delivery systems
• Direct experience in LNP formulation (in-line mixing and TFF), characterization (DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis, etc.), mRNA and siRNA encapsulation, and QC analysis is a must
• Experience in high-throughput formulation screening will be plus
• Experience in antibody, peptide, or small molecule formulations/analysis and drug delivery systems will be plus
• Ability to work on multiple projects simultaneously and deliver conclusive results
• Quickly adapt to new priorities with responsibility in a fast-paced, dynamic, innovative environment
• Goal oriented, highly organized with significant attention to details while maintaining highest scientific and ethical standards
• Strategic and forward thinking
• Strong team player with excellent verbal and written communication skills